Department of Clinical Pathology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Neurology, Sijhih Cathay General Hospital, New Taipei City, Taiwan.
Am J Med. 2022 Aug;135(8):1001-1007. doi: 10.1016/j.amjmed.2022.04.029. Epub 2022 May 14.
Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.
This retrospective cohort study enrolled 107,207 patients with newly diagnosed hypertension between 2001 and 2013. The hazard ratios for Parkinson disease were calculated for ARB treatment compared with those who never used ARBs and among the 5 subgroups receiving different cumulative ARB dosages.
We identified 527 (1.1%) Parkinson disease cases among patients with ARB treatment in a median observation period of 8.4 years compared to the 1,255 (2.2%) Parkinson disease cases among those without ARB treatment in a median observation period of 6.8 years. Overall, risk for developing Parkinson disease was statistically lower in the ARB-treated group with a hazard ratio of 0.56 (95% confidence interval: 0.51-0.63) than those without ARB.
ARB treatment was associated with a statistically important reduction of Parkinson disease risk in patients with newly diagnosed hypertension. Therefore, ARB may constitute an effective neuroprotective strategy to lower Parkinson disease risk in such patients.
血管紧张素受体阻滞剂（ARBs）是常用的降压药，基于动物和体外研究，它们通过降低氧化应激来降低帕金森病的风险。因此，本研究旨在测试新诊断高血压患者中这种相关性。
这项回顾性队列研究纳入了 2001 年至 2013 年间新诊断为高血压的 107207 名患者。与从未使用过 ARB 的患者相比，在接受不同累积 ARB 剂量的 5 个亚组中，计算 ARB 治疗与帕金森病的风险比。
在中位观察期为 8.4 年的 ARB 治疗组中，我们发现了 527 例（1.1%）帕金森病病例，而在中位观察期为 6.8 年的未使用 ARB 治疗组中，发现了 1255 例（2.2%）帕金森病病例。总体而言，ARB 治疗组发生帕金森病的风险明显低于未使用 ARB 治疗组，风险比为 0.56（95%置信区间：0.51-0.63）。
在新诊断为高血压的患者中，ARB 治疗与帕金森病风险的统计学显著降低相关。因此，ARB 可能构成一种有效的神经保护策略，以降低此类患者的帕金森病风险。
