代谢谱在评估 HPV 感染状态改变对阴道微环境的反应方面优于微生物组。
Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection.
机构信息
Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.
出版信息
NPJ Biofilms Microbiomes. 2024 Mar 20;10(1):26. doi: 10.1038/s41522-024-00500-0.
There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.
目前基于人群的研究中，对于 HPV 感染对阴道微环境的影响及其对持续性 HPV 感染风险的影响仍不清楚。本前瞻性研究旨在阐明 HPV 感染状态改变时阴道微生物群（VM）和阴道代谢组的动态变化。我们的研究结果表明，在评估 HPV 状态改变对阴道微环境的影响时，阴道代谢组可能是 VM 的更好指标。
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