子痫前期母亲的 6 个月大婴儿血管反应性降低与白细胞介素 8 增加有关。
Decreased vascular reactivity associated with increased IL-8 in 6-month-old infants of mothers with pre-eclampsia.
机构信息
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Pediatrics, Division of Pediatric Pulmonology, University of Nebraska Medical Center, Omaha, NE, USA.
出版信息
Pediatr Res. 2024 Sep;96(4):976-982. doi: 10.1038/s41390-024-03132-4. Epub 2024 Mar 20.
BACKGROUND
Offspring born to mothers with pre-eclampsia (Pre-E) suffer higher risks of adult cardiovascular diseases, suggesting that exposure to an antiangiogenic environment in-utero has a lasting impact on the development of endothelial function. The goal of this study is to test the hypothesis that in-utero exposure to Pre-E results in alterations of angiogenic factors/cytokines that negatively impact vascular development during infancy.
METHODS
Infants born from mothers with and without Pre-E were recruited and followed up at 6 months. Plasma cytokines, blood pressure, microvessel density, and vascular reactivity were assessed.
RESULTS
6-month-old infants born to mothers with Pre-E had unchanged blood pressure (p = 0.86) and microvessel density (p = 0.57). Vascular reactivity was decreased in infants born to mothers with Pre-E compared to infants born to healthy mothers (p = 0.0345). Interleukin 8 (IL-8) (p = 0.03) and Angiopoeitin-2 (Ang-2) (p = 0.04) were increased in infants born to mothers with Pre-E. We observed that higher IL-8 was associated with lower vascular reactivity (rho = -0.14, p < 0.0001).
CONCLUSION
At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers.
IMPACT STATEMENT
Changes in cord blood antiangiogenic factors are documented in infants of mothers with pre-eclampsia and may contribute to offspring risks of adult cardiovascular disease. How these factors evolve during early infancy and their correlation with offspring vascular development have not been studied. This study found that 6-month-old infants born to mothers with pre-eclampsia had decreased vascular reactivity, which was correlated with higher IL-8. These findings underscore the lasting impact of maternal pre-eclampsia on offspring vascular development and highlight the need for long-term follow-up in children born to mothers with pre-eclampsia.
背景
患有先兆子痫（Pre-E）的母亲所生的后代成年后患心血管疾病的风险更高，这表明子宫内暴露于抗血管生成环境会对内皮功能的发育产生持久影响。本研究的目的是检验这样一个假设，即在子宫内暴露于 Pre-E 会导致血管生成因子/细胞因子发生变化，从而对婴儿期的血管发育产生负面影响。
方法
招募了患有和不患有 Pre-E 的母亲所生的婴儿，并在 6 个月时进行随访。评估了血浆细胞因子、血压、微血管密度和血管反应性。
结果
与健康母亲所生的婴儿相比，患有 Pre-E 的母亲所生的 6 个月大的婴儿的血压没有变化（p=0.86），微血管密度也没有变化（p=0.57）。与健康母亲所生的婴儿相比，患有 Pre-E 的母亲所生的婴儿的血管反应性降低（p=0.0345）。白细胞介素 8（IL-8）（p=0.03）和血管生成素-2（Ang-2）（p=0.04）在患有 Pre-E 的母亲所生的婴儿中增加。我们观察到，较高的 IL-8 与较低的血管反应性相关（rho=-0.14，p<0.0001）。
结论
在 6 个月大时，患有 Pre-E 的母亲所生的婴儿的血管反应性降低，IL-8 和 Ang-2 水平升高，但与非 Pre-E 母亲所生的婴儿相比，血压和微血管密度相似。
影响
在患有先兆子痫的母亲的婴儿脐带血中发现了抗血管生成因子的变化，这可能导致后代成年后患心血管疾病的风险增加。这些因子在婴儿早期如何演变及其与后代血管发育的相关性尚未得到研究。本研究发现，患有先兆子痫的母亲所生的 6 个月大的婴儿血管反应性降低，这与 IL-8 升高有关。这些发现强调了母体先兆子痫对后代血管发育的持久影响，并突出了对患有先兆子痫的母亲所生的儿童进行长期随访的必要性。
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