Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel.
Department of Pediatrics, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Pediatr Pulmonol. 2020 Mar;55(3):723-728. doi: 10.1002/ppul.24659. Epub 2020 Jan 27.
Pre-eclampsia has a considerable effect on the intrauterine environment, yet not much is understood about how this impacts the respiratory health of the offspring. The aim of the present study is to determine if pre-eclampsia correlates with a higher incidence of respiratory disease in the offspring.
This cohort study assessed the differences in respiratory disease patterns between singletons born to mothers with and without pre-eclampsia. The study was conducted between 1991 and 2014 in a regional tertiary medical center. A generalized estimating equation (GEE) model was used to control for confounders and maternal clusters.
253 808 deliveries were included in the study. Of these, 3.0% were to mothers diagnosed with pre-eclampsia (n = 7660), 0.9% with severe pre-eclampsia (n = 2366), and 0.03% with eclampsia (n = 81). A significant linear association was noted between the severity of the pre-eclampsia (no pre-eclampsia, mild, severe pre-eclampsia, and eclampsia) and respiratory disease of the offspring (5.7%, vs 6.0% vs 7.3% vs 9.9%, respectively; P = .003). The offspring of mothers who developed pre-eclampsia had significantly higher rates of asthma (1.1%, vs 1.3% vs 1.4% vs 1.2% correspondingly; P = .018). In the GEE model, controlling for gestational diabetes, maternal age, gestational age, and length of follow up, pre-eclampsia was found to be an independent risk factor for respiratory morbidity in the offspring (adjusted odds ratio = 1.32; 95% confidence interval, 1.21-1.45).
Exposure to maternal pre-eclampsia is an independent risk factor for long-term respiratory morbidity in the offspring. Specifically, the prenatal exposure to pre-eclampsia was significantly associated with asthma of the offspring.
子痫前期对宫内环境有很大影响，但人们对其如何影响后代的呼吸健康知之甚少。本研究旨在确定子痫前期是否与后代呼吸疾病的发生率更高相关。
本队列研究评估了患有和不患有子痫前期的母亲所生单胎的呼吸疾病模式差异。该研究于 1991 年至 2014 年在一家地区性三级医疗中心进行。使用广义估计方程（GEE）模型来控制混杂因素和母体聚类。
本研究纳入了 253808 例分娩。其中，3.0%的母亲被诊断为子痫前期（n=7660），0.9%为重度子痫前期（n=2366），0.03%为子痫（n=81）。研究发现，子痫前期的严重程度（无子痫前期、轻度子痫前期、重度子痫前期和子痫）与后代的呼吸疾病之间存在显著的线性关联（分别为 5.7%、6.0%、7.3%和 9.9%；P=0.003）。患有子痫前期的母亲的后代哮喘发病率明显更高（1.1%、1.3%、1.4%和 1.2%；相应的 P=0.018）。在 GEE 模型中，控制了妊娠期糖尿病、母亲年龄、胎龄和随访时间后，子痫前期被发现是后代呼吸发病率的独立危险因素（调整后的优势比=1.32；95%置信区间，1.21-1.45）。
母体子痫前期的暴露是后代长期呼吸发病率的独立危险因素。具体来说，产前暴露于子痫前期与后代哮喘显著相关。
