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Complement C1q induces the M2-polarization of tumor-associated macrophages in lung adenocarcinoma.

作者信息

Song Yuxiao, Fu Yang, Wang Jun, Tang Jiazhuo, Yin Jiaxin, Zhang Zhimin, Song Qibin, Zhang Bicheng

机构信息

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430061, China.

Department of Oncology, Xiangyang Hospital, Hubei University of Chinese Medicine, Xiangyang, Hubei 441100, China.

出版信息

Genes Dis. 2023 Sep 13;11(4):101093. doi: 10.1016/j.gendis.2023.101093. eCollection 2024 Jul.

DOI:10.1016/j.gendis.2023.101093
PMID:38510481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10951452/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8313/10951452/4bfecca2ae6f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8313/10951452/4bfecca2ae6f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8313/10951452/4bfecca2ae6f/gr1.jpg

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本文引用的文献

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Complement activation in cancer: Effects on tumor-associated myeloid cells and immunosuppression.补体激活在癌症中的作用：对肿瘤相关髓系细胞和免疫抑制的影响。
Semin Immunol. 2022 Mar;60:101642. doi: 10.1016/j.smim.2022.101642. Epub 2022 Jul 14.
2
The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway.紫菀酮通过ECM1/STAT5/NF-κB通路对脓毒症诱导的急性肺损伤的影响
Front Pharmacol. 2022 Jan 26;12:764247. doi: 10.3389/fphar.2021.764247. eCollection 2021.
3
High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis.
肿瘤相关巨噬细胞中 NLRP12/C1qA 的正反馈通过 LILRB4/NF-κB 通路调节肺腺癌的免疫抑制。
Cancer Immunol Immunother. 2024 Nov 11;74(1):16. doi: 10.1007/s00262-024-03880-6.
4
Increasing serum complement component 1q is associated with worse prognosis in advanced non-small cell lung cancer treated with immune checkpoint inhibitors: a single-center, retrospective study.血清补体成分C1q升高与接受免疫检查点抑制剂治疗的晚期非小细胞肺癌预后较差相关：一项单中心回顾性研究。
J Thorac Dis. 2024 May 31;16(5):3251-3259. doi: 10.21037/jtd-24-304. Epub 2024 May 24.
肺纤维化和非小细胞肺癌中高补体蛋白 C1q 水平与预后不良相关。
BMC Cancer. 2022 Jan 25;22(1):110. doi: 10.1186/s12885-021-08912-3.
4
Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma.整合基因组和转录组分析揭示了胰腺导管腺癌肝转移的独特特征和补体 C1q 的促转移作用。
Genome Biol. 2021 Jan 4;22(1):4. doi: 10.1186/s13059-020-02222-w.
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Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner.紫杉醇通过 TLR4 依赖性方式将肿瘤相关巨噬细胞重编程为 M1 样表型，从而抑制肿瘤生长。
Cancer Res. 2018 Oct 15;78(20):5891-5900. doi: 10.1158/0008-5472.CAN-17-3480. Epub 2018 Aug 13.