Konoshita Naohiro, Onishi Hidenori, Mizukami Yasutaka, Ikeda Ryouko, Tanaka Tokuharu, Tsubouchi Hiromasa, Kishimoto Takahiro, Hayashi Hiroyuki, Yamamura Osamu
Eiheiji Town Home Visit Care Clinic, 38-45 Matsuokakenjoujima, Yoshida-gun, Eiheiji-cho, Fukui 910-1142, Japan.
Department of Family Medicine, University of Fukui Hospital, 23-3 Matsuokashimoaizuki, Yoshida-gun, Eiheiji-cho, Fukui 910-1104, Japan.
J Clin Biochem Nutr. 2024 Mar;74(2):154-161. doi: 10.3164/jcbn.23-88. Epub 2023 Oct 17.
The simplification of diagnostic criteria is critical to promoting interventions for sarcopenia. This study aimed to evaluate the relationship between sarcopenia and bone mass [measured by bioelectrical impedance analysis (BIA)], as well as to identify new indicators associated with this disease. Basic interviews and measurement of physical function were performed on 474 community-dwelling older adults (aged 77.1 ± 7.6 years), including older adult patients with sarcopenia, in Wakasa Town, Fukui Prefecture. The findings led to 363, 71, and 40 participants being classified as 'normal', 'pre-sarcopenia', and 'having sarcopenia', respectively. An Ordinal Logistic Regression Analysis showed that age, bone mass phase angle (lower limb), Fat-free Mass Index, and leg muscle score were aggravating factors for sarcopenia in both men and women. A receiver operating characteristic analysis of bone mass and sarcopenia status showed that the area under the curve and cut-off value, as well as its sensitivity and specificity, in men were 0.915 [95% confidence interval (CI): 0.853-0.977], 2.2 kg, 81%, and 87%, respectively, and 0.913 (95% CI: 0.858-0.968), 1.6 kg, 91%, and 88%, respectively, in women. This study revealed that the BIA method of measuring bone mass has excellent accuracy in detecting sarcopenia in both males and females.
简化诊断标准对于促进肌肉减少症的干预措施至关重要。本研究旨在评估肌肉减少症与骨量[通过生物电阻抗分析（BIA）测量]之间的关系，并确定与该疾病相关的新指标。对福井县若狭町474名社区居住的老年人（年龄77.1±7.6岁）进行了基础访谈和身体功能测量，其中包括患有肌肉减少症的老年患者。结果导致363名、71名和40名参与者分别被归类为“正常”、“肌肉减少症前期”和“患有肌肉减少症”。有序逻辑回归分析表明，年龄、骨量相位角（下肢）、去脂体重指数和腿部肌肉评分是男性和女性肌肉减少症的加重因素。骨量与肌肉减少症状态的受试者工作特征分析表明，男性的曲线下面积和临界值及其敏感性和特异性分别为0.915[95%置信区间（CI）：0.853 - 0.977]、2.2 kg、81%和87%，女性分别为0.913（95%CI：0.858 - 0.968）、1.6 kg、91%和88%。本研究表明，通过BIA方法测量骨量在检测男性和女性肌肉减少症方面具有出色的准确性。
