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小儿肝移植患者急性肾损伤的发病率及危险因素:一项回顾性研究

Incidence and Risk Factors of Acute Kidney Injury in Pediatric Liver Transplant Patients: A Retrospective Study.

作者信息

Demiroz Duygu, Colak Yusuf Ziya, Ozdes Oya Olcay, Ucar Muharrem, Erdogan Mehmet Ali, Toprak Hüseyin Ilksen, Karakas Serdar, Tasolar Sevgi Demiroz, Aydın Cemalettin, Varol Ilknur

机构信息

Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey.

Department of Anesthesiology and Reanimation, School of Medicine, Aydın University, Istanbul, Turkey.

出版信息

Indian J Crit Care Med. 2024 Jan;28(1):75-79. doi: 10.5005/jp-journals-10071-24616.

DOI:10.5005/jp-journals-10071-24616
PMID:38510757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10949289/
Abstract

BACKGROUND

Acute kidney injury (AKI) significantly contributes to the mortality and morbidity rates among pediatric liver transplant (LT) recipients.

OBJECTIVE

Our study aimed to assess the potential factors contributing to AKI in pediatric LT patients and to analyze the impact of AKI on postoperative mortality and hospitalization duration.

MATERIALS AND METHODS

About 235 pediatric LT patients under the age of 18 between the years 2015 and 2021 were evaluated retrospectively. The relationship between preoperative and intraoperative variables of the patients and AKI developed when the early postoperatıve period was assessed.

RESULTS

A correlation was found between the patients' preoperative age, albumin levels, and AKI. AKI was found to be associated with the duration of surgery and intraoperative blood transfusion.

CONCLUSION

Our findings revealed that the severity of AKI in pediatric LT patients is linked to extended surgical durations and increased blood transfusions resulting from hemodynamically compromised blood loss. Furthermore, independent risk factors for AKI were identified as prolonged warm ischemia and the overall duration of the operation.

HOW TO CITE THIS ARTICLE

Demiroz D, Colak YZ, Ozdes OO, Ucar M, Ali Erdogan M, Toprak HI, . Incidence and Risk Factors of Acute Kidney İnjury in Pediatric Liver Transplant Patients: A Retrospective Study. Indian J Crit Care Med 2024;28(1):75-79.

摘要

背景

急性肾损伤(AKI)显著增加了小儿肝移植(LT)受者的死亡率和发病率。

目的

我们的研究旨在评估小儿LT患者发生AKI的潜在因素,并分析AKI对术后死亡率和住院时间的影响。

材料与方法

回顾性评估了2015年至2021年间235例18岁以下的小儿LT患者。评估患者术前和术中变量与术后早期发生AKI之间的关系。

结果

发现患者术前年龄、白蛋白水平与AKI之间存在相关性。发现AKI与手术时间和术中输血有关。

结论

我们的研究结果表明,小儿LT患者AKI的严重程度与手术时间延长以及因血流动力学受损失血导致的输血增加有关。此外,AKI的独立危险因素被确定为长时间热缺血和手术总时长。

如何引用本文

Demiroz D, Colak YZ, Ozdes OO, Ucar M, Ali Erdogan M, Toprak HI, . 小儿肝移植患者急性肾损伤的发生率及危险因素:一项回顾性研究。《印度重症监护医学杂志》2024;28(1):75 - 79。

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本文引用的文献

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OPTN/SRTR 2018 Annual Data Report: Liver.OPTN/SRTR 2018 年度数据报告:肝脏。
Am J Transplant. 2020 Jan;20 Suppl s1:193-299. doi: 10.1111/ajt.15674.
2
Preoperative hypoalbuminemia was associated with acute kidney injury in high-risk patients following non-cardiac surgery: a retrospective cohort study.术前低白蛋白血症与非心脏手术后高危患者的急性肾损伤相关:一项回顾性队列研究。
BMC Anesthesiol. 2019 Sep 2;19(1):171. doi: 10.1186/s12871-019-0842-3.
3
Effect of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantation.七氟醚和丙泊酚对小儿活体供肝肝移植中急性肾损伤的影响。
Ann Transl Med. 2019 Jul;7(14):340. doi: 10.21037/atm.2019.06.76.
4
Risk factors and associated outcomes of early acute kidney injury in pediatric liver transplant recipients: A retrospective study.儿科肝移植受者早期急性肾损伤的风险因素及相关结局:一项回顾性研究。
J Pediatr Surg. 2020 Mar;55(3):446-450. doi: 10.1016/j.jpedsurg.2019.07.019. Epub 2019 Aug 13.
5
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6
Early Postoperative Acute Kidney Injury Among Pediatric Liver Transplant Recipients.小儿肝移植受者术后早期急性肾损伤
Exp Clin Transplant. 2021 Jul;19(7):659-663. doi: 10.6002/ect.2018.0214. Epub 2019 Mar 14.
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