Weerasuriya A, Bieger D, Hockman C H
Brain Res. 1979 Sep 28;174(1):119-33. doi: 10.1016/0006-8993(79)90808-4.
In adult cats anaesthetized with urethane, electrical and chemical stimulation of the basal forebrain facilitated reflex swallowing elicited by electrical stimulation of the superior laryngeal nerve. A systematic stereotaxic mapping study using electrical stimulation revealed that the facilitatory sites were distributed along the course of the ansa peduncularis, specifically its rostral forebrain and hypothalamic components associated with the anterior amygdalar area, substantia innominata, lateral preoptic area, anterior hypothalamus and nucleus accumbens. By means of acute discrete radiofrequency lesions, the descending pathways mediating facilitatory influences from the nucleus accumbens and the amygdala to the brain stem were found to traverse the lateral hypothalamus. Ventral tegmental facilitatory sites in the midbrain are likely to be associated with these descending pathways; however, there is evidence for independent participation of this region of the brain in the control of swallowing. Chemical stimulation by means of microinjections of dopamine and apomorphine into the amygdala and nucleus accumbens also enhanced reflex swallowing. It is concluded that the results of this investigation implicate the basal forebrain as a site of integration of viscero-olfacto-gustatory information needed for the enactment of ingestive behaviour.
在用氨基甲酸乙酯麻醉的成年猫中，对基底前脑进行电刺激和化学刺激，可促进由喉上神经电刺激引发的反射性吞咽。一项使用电刺激的系统性立体定位图谱研究表明，促进性位点沿脚周袢分布，特别是其与杏仁前区、无名质、视前外侧区、下丘脑前部和伏隔核相关的前脑和下丘脑部分。通过急性离散射频损伤发现，介导伏隔核和杏仁核向脑干的促进性影响的下行通路穿过外侧下丘脑。中脑腹侧被盖区的促进性位点可能与这些下行通路有关；然而，有证据表明该脑区在吞咽控制中独立发挥作用。通过向杏仁核和伏隔核微量注射多巴胺和阿扑吗啡进行化学刺激也增强了反射性吞咽。得出的结论是，这项研究结果表明基底前脑是摄取行为所需的内脏 - 嗅觉 - 味觉信息整合的部位。
