仔猪实验性肠道大肠杆菌病的产前免疫
Prenatal immunization against experimental enteric colibacillosis in piglets.
作者信息
Gay C C
出版信息
Can J Comp Med. 1979 Jul;43(3):237-42.
Abstract
To establish a model for the study of prenatal immunization against enteric colibacillosis a proportion of the litters of seven sows were immunized in utero 18 to 22 days before term by intra-amniotic and intramuscular injection of Escherichia coli antigen and the litters challenged at birth with either homologous or heterologous strains. Protection against homologous challenge was demonstrated in some but not all vaccinated piglets. The study was severely compromised by the occurrence of intrauterine death in a significant proportion of vaccinated piglets.
摘要
为建立产前免疫预防肠道大肠杆菌病的研究模型，在妊娠期满前18至22天，通过羊膜内和肌肉注射大肠杆菌抗原，对7头母猪的部分仔猪进行子宫内免疫，然后在出生时用同源或异源菌株对这些仔猪进行攻毒。部分但并非所有接种疫苗的仔猪都表现出对同源攻毒的保护作用。该研究因相当一部分接种疫苗的仔猪发生宫内死亡而受到严重影响。
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