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新西兰怀卡托地区巨细胞动脉炎快速通道的表现。

Performance of a fast-track pathway for giant cell arteritis in Waikato, Aotearoa New Zealand.

机构信息

Rheumatology Department, Te Whatu Ora, Waikato Hospital, Hamilton, New Zealand.

Rheumatology Department, Te Whatu Ora, Waikato Hospital, Hamilton, New Zealand; Waikato Clinical School, The University of Auckland, Hamilton, New Zealand.

出版信息

N Z Med J. 2024 Mar 22;137(1592):31-42. doi: 10.26635/6965.6376.

Abstract

AIMS

Giant cell arteritis (GCA) is the most common primary vasculitis in adults over 50 years of age. To facilitate early diagnosis and reduce harms from corticosteroids and temporal artery biopsies, fast-track pathways have been established. We review the benefits of the fast-track pathway set up in Waikato, Aotearoa New Zealand.

METHODS

Patients were collected prospectively as part of the fast-track pathway from 2014 to 2022. Their records were then reviewed retrospectively to collect data on clinical features, investigations and treatment.

RESULTS

There were 648 individual patients over the study period who had a colour Doppler ultrasound (CDUS) of the temporal arteries. There were 17 true positive CDUS, giving a sensitivity of 10.3% (95% confidence interval [CI] 6.3-15.5%) and specificity of 99.8% (95% CI 99.1-100%). Patients with GCA and a positive scan had significantly fewer steroids than those with GCA and a negative scan (p=0.0037). There were 376 patients discharged after a CDUS who did not have a diagnosis of GCA, resulting in reduced corticosteroid and temporal artery biopsy exposure.

CONCLUSIONS

This is a real-life study that reflects the benefits of fast-track pathways in Aotearoa New Zealand to patients and healthcare systems. It also shows the effect of corticosteroids on positive CDUS, an important consideration when setting up an fast-track pathway.

摘要

目的

巨细胞动脉炎(GCA)是 50 岁以上成年人中最常见的原发性血管炎。为了促进早期诊断并减少皮质类固醇和颞动脉活检的危害,已经建立了快速通道。我们回顾了新西兰怀卡托地区建立的快速通道的益处。

方法

作为快速通道的一部分,前瞻性地收集了 2014 年至 2022 年期间的患者。然后回顾性地审查他们的记录,以收集有关临床特征、检查和治疗的数据。

结果

在研究期间,共有 648 名患者接受了颞动脉彩色多普勒超声(CDUS)检查。有 17 例 CDUS 阳性,灵敏度为 10.3%(95%置信区间[CI]6.3-15.5%),特异性为 99.8%(95% CI 99.1-100%)。GCA 患者中 CDUS 阳性扫描的患者比 CDUS 阴性扫描的患者使用的皮质类固醇明显减少(p=0.0037)。有 376 名接受 CDUS 检查后未被诊断为 GCA 的患者出院,从而减少了皮质类固醇和颞动脉活检的暴露。

结论

这是一项真实世界的研究,反映了新西兰快速通道对患者和医疗保健系统的益处。它还显示了皮质类固醇对阳性 CDUS 的影响,这是在建立快速通道时需要考虑的重要因素。

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