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肌肉注射卡替拉韦和利匹韦林长效复方制剂的患者中诊断出的 HIV 合并感染。

A HIV Superinfection Diagnosed in a Patient on Intramuscular Long-acting Combination of Cabotegravir and Rilpivirine.

机构信息

Department of Infectious and Tropical Diseases, Saint Antoine Hospital, Paris, France.

Virology Department, Sorbonne University, Saint-Antoine Hospital, AP-HP, Pierre Louis Epidemiology and Public Health Institute (iPLESP), INSERM 1136, Paris, France.

出版信息

Clin Infect Dis. 2024 Jul 19;79(1):196-197. doi: 10.1093/cid/ciad757.

DOI:10.1093/cid/ciad757
PMID:38513236
Abstract

A case of a male with human immunodeficiency virus with plasma genotyping detecting no resistance and a CRF02_AG subtype had a controlled HIV RNA on antiretroviral therapy since 2010. We introduced intramuscular therapy with cabotegravir and rilpivirine. One month later, his HIV RNA was 1500 copies/mL; genotyping found a subtype B with many mutations.

摘要

一名男性艾滋病毒感染者,2010 年开始接受抗逆转录病毒治疗,其血浆基因分型检测无耐药性,且为 CRF02_AG 亚型,HIV RNA 得到控制。我们开始采用卡替拉韦和利匹韦林进行肌内注射治疗。一个月后,他的 HIV RNA 为 1500 拷贝/毫升;基因分型发现存在多种突变的 B 亚型。

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引用本文的文献

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Therapeutic Drug Monitoring of Long-Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection-A Case Series of Five Patients With One Virologic Failure After Development of Two-Class Resistance.长效利匹韦林和卡博特韦治疗HIV-1感染的治疗药物监测——五例患者病例系列,其中一例在出现两类耐药后出现病毒学失败
Open Forum Infect Dis. 2024 Aug 23;11(9):ofae480. doi: 10.1093/ofid/ofae480. eCollection 2024 Sep.