Department of Analytical Chemistry and Food Technology, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, Camilo José Cela Av. s/n, Ciudad Real 13071, Spain; Regional Institute for Applied Scientific Research, IRICA, University of Castilla-La Mancha, Camilo José Cela Av. s/n, Ciudad Real 13071, Spain.
Regional Institute for Applied Scientific Research, IRICA, University of Castilla-La Mancha, Camilo José Cela Av. s/n, Ciudad Real 13071, Spain; Department of Analytical Chemistry and Food Technology, Faculty of Pharmacy, University of Castilla-La Mancha, Dr. José María Sánchez Ibáñez Av. s/n, Albacete 02071, Spain.
J Pharm Biomed Anal. 2024 Jun 15;243:116118. doi: 10.1016/j.jpba.2024.116118. Epub 2024 Mar 17.
This review summarizes recent progress performed in the design and application of analytical tools and methodologies using nanomaterials for pharmaceutical analysis, and specifically new nanomedicines at distinct phases of development and translation from preclinical to clinical stages. Over the last 10-15 years, a growing number of studies have utilized various nanomaterials, including carbon-based, metallic nanoparticles, polymeric nanomaterials, materials based on biological molecules, and composite nanomaterials as tools for improving the analysis of pharmaceutical products. New and more complex nanomaterials are currently being explored to influence different stages of the analytical process. These materials provide unique properties to support the extraction of analytes in complex samples, increase the selectivity and efficiency of chromatographic separations, and improve the analytical properties of many sensor applications. Indeed, nanomaterials, including electrochemical detection approaches and biosensing, are expanding at a remarkable rate. Furthermore, the analytical performance of numerous approaches to determine drugs in different matrices can be significantly improved in terms of precision, detection limits, selectivity, and time of analysis. However, the quality control and metrological characterization of the currently synthesized nanomaterials still depend on the development of new and improved analytical methodologies, and the application of specific and improved instrumentation. Therefore, there is still much to explore about the properties of nanomaterials which need to be determined even more precisely and accurately.
本文综述了近年来在利用纳米材料进行药物分析的分析工具和方法的设计和应用方面取得的进展，特别是在从临床前阶段到临床阶段的不同阶段开发和转化的新型纳米药物。在过去的 10-15 年中，越来越多的研究利用了各种纳米材料，包括碳基、金属纳米粒子、聚合物纳米材料、基于生物分子的材料和复合纳米材料，作为改进药物产品分析的工具。目前正在探索新的和更复杂的纳米材料来影响分析过程的不同阶段。这些材料提供了独特的性质，支持在复杂样品中提取分析物，提高色谱分离的选择性和效率，并改善许多传感器应用的分析性能。事实上，纳米材料（包括电化学检测方法和生物传感）正在以惊人的速度发展。此外，许多方法在不同基质中测定药物的分析性能可以在精密度、检测限、选择性和分析时间方面得到显著提高。然而，目前合成的纳米材料的质量控制和计量学特性仍然取决于新的和改进的分析方法的发展，以及特定和改进的仪器的应用。因此，仍然需要更精确和准确地确定纳米材料的性质。
