Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, People's Republic of China.
Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, People's Republic of China.
Int J Cardiol. 2024 Jul 15;407:131985. doi: 10.1016/j.ijcard.2024.131985. Epub 2024 Mar 19.
Radiofrequency ablation (RFA) has been a central therapeutic strategy for ventricular tachycardia (VT). However, concerns about its long-term effectiveness and complications have arisen. Pulsed field ablation (PFA), characterized by its nonthermal, highly tissue-selective ablation technique, has emerged as a promising alternative. This comprehensive review delves into the potential advantages and opportunities presented by PFA in the realm of VT, drawing insights from both animal experimentation and clinical case studies. PFA shows promise in generating superior lesions within scarred myocardial tissue, and its inherent repetition dependency holds the potential to enhance therapeutic outcomes. Clinical cases underscore the promise of PFA for VT ablation. Despite its promising applications, challenges such as catheter maneuverability and proarrhythmic effects require further investigation. Large-scale, long-term studies are essential to establish the suitability of PFA for VT treatment.
射频消融(RFA)一直是治疗室性心动过速(VT)的核心治疗策略。然而,人们对其长期有效性和并发症的担忧也随之而来。脉冲场消融(PFA)以其非热、高度组织选择性消融技术为特点,已成为一种很有前途的替代方法。本综述深入探讨了 PFA 在 VT 领域中具有的潜在优势和机会,从动物实验和临床案例研究中汲取了见解。PFA 在产生瘢痕心肌组织内更好的消融损伤方面具有潜力,其固有的重复依赖性有可能提高治疗效果。临床案例强调了 PFA 在心律失常消融方面的应用前景。尽管具有广阔的应用前景,但仍存在一些挑战,如导管操控性和致心律失常作用等,需要进一步研究。需要进行大规模、长期的研究,以确定 PFA 治疗 VT 的适宜性。