Rajaie Cardiovascular Medical and Research Institue, Iran University of Medical Sciences, Tehran, Iran.
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Cardiol. 2024 Oct;47(10):e70018. doi: 10.1002/clc.70018.
Pulsed-field ablation (PFA) is a cutting-edge technique that employs non-thermal energy to cause cell death by inducing irreversible electroporation of cell membranes. This systematic review evaluates the PFA effectiveness as a potential alternative to radiofrequency and cryo-ablation for treating ventricular tachycardia.
PubMed, Embase, Scopus, and Web of Science were systematically searched using keywords related to ventricular tachycardia and pulsed-field ablation. Eligible Studies evaluating this therapeutic approach for ventricular tachycardia were included in the final analysis.
We included six studies (five case reports and one case series) in our systematic review. Eight (88.8%) of procedures were successful with 100% long-term efficacy. No procedural complications or ventricular tachycardia (VT) recurrence were observed in the cases.
The absence of complications, high effectiveness, and long-term success rate make PFAs a good VT treatment option. However, PFA safety and efficacy studies for VT treatment are scarce. Thus, larger investigations on this topic are urgently needed.
脉冲场消融（PFA）是一种前沿技术，通过诱导细胞膜不可逆电穿孔来利用非热能杀死细胞。本系统评价评估了 PFA 在治疗室性心动过速方面作为射频和冷冻消融替代疗法的潜在效果。
使用与室性心动过速和脉冲场消融相关的关键词，系统地在 PubMed、Embase、Scopus 和 Web of Science 中进行了搜索。最终分析中纳入了评估这种治疗方法治疗室性心动过速的合格研究。
我们的系统评价纳入了 6 项研究（5 个病例报告和 1 个病例系列）。8 项（88.8%）程序成功，长期有效率为 100%。病例中未观察到任何程序并发症或室性心动过速（VT）复发。
无并发症、高有效性和长期成功率使 PFA 成为治疗 VT 的良好选择。然而，关于 PFA 治疗 VT 的安全性和有效性研究很少。因此，迫切需要对此主题进行更大规模的研究。
