School of Health and Sports Sciences, Hope Park, Liverpool Hope University, Liverpool L16 9JD, United Kingdom.
School of Science, Engineering and Environment, University of Salford Manchester, Salford M5 4NT, United Kingdom.
Ageing Res Rev. 2024 Apr;96:102278. doi: 10.1016/j.arr.2024.102278. Epub 2024 Mar 19.
Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically examine some of the factors which have been revealed to modulate VaD risk. The survey commences by providing an overview of the putative mechanisms which are associated with the pathobiology of VaD. Next, the factors which influence the risk of developing VaD are examined. Finally, emerging treatment avenues including epigenetics, the gut microbiome, and pro-longevity pharmaceuticals are discussed. By drawing this key evidence together, it is our hope that it can be used to inform future experimental investigations in this field.
血管性痴呆（VaD）是第二常见的痴呆类型。VaD 与衰老同义，其症状给老年人的健康和福祉带来了巨大负担。尽管已经确定了大量 VaD 的风险因素，但这种疾病的病理机制仍有待充分阐明。因此，生物老年学有必要强调可以减轻患 VaD 风险的可改变生活方式因素。本综述将批判性地检查一些已被揭示可调节 VaD 风险的因素。该调查首先概述了与 VaD 病理生物学相关的假定机制。接下来，检查了影响 VaD 发病风险的因素。最后，讨论了新兴的治疗途径，包括表观遗传学、肠道微生物组和延长寿命的药物。通过将这些关键证据汇集在一起，我们希望它可以用于为该领域的未来实验研究提供信息。
