Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, 413 avenue Eugène Avinée 59120 LOOS, F-59000 Lille, France; Institut de Recherches Cliniques de Montréal, 110 Av. des Pins, Montréal, QC H2W 1R7, Canada.
Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, 413 avenue Eugène Avinée 59120 LOOS, F-59000 Lille, France.
Diabetes Res Clin Pract. 2024 Apr;210:111631. doi: 10.1016/j.diabres.2024.111631. Epub 2024 Mar 20.
From an early age, exercise is key to managing type 1 diabetes (T1D). However, hypoglycemia around aerobic exercise is a major barrier to physical activity in children. We explore whether intermittent high-intensity aerobic exercise (IHE), designed to mimic spontaneous childhood physical activity patterns, offers better protection against glycemic drop than continuous moderate-intensity exercise (CME).
Five boys and 7 girls with T1D (9.8 ± 1.4y) performed ergo cycle-based randomized CME and IHE of identical duration and total mechanical load [50 %PWCvs. 15sec(150 %PWC)/30 sec passive recovery; both during two 10-min sets, 5 min in-between]. Capillary glycemia during exercise and interstitial glucose during recovery were compared between exercises and an inactive condition, controlling for baseline glycemia, carbohydrate and insulin.
The exercise-induced decrease in capillary glycemia was attenuated by 1.47 mmol·L for IHE vs. CME (P < 0.05). No symptomatic hypoglycemic episodes occurred during exercises. Post-exercise time in hypoglycemia did not differ between conditions. During early recovery, CME reduced time spent > 16.7 mmol·L compared with inactive days (P < 0.05; CME: 0 %; IHE: 16,7 %; INACTIVE: 41,7 %).
IHE appeared to limit the glycemic drop compared to CME. Performing 20-min CME or IHE was not associated with increased hypoglycemic risk compared to being inactive. CME appeared even transiently protective against serious hyperglycemia.
从幼年开始，运动对于 1 型糖尿病（T1D）的管理至关重要。然而，有氧运动时的低血糖是儿童进行体育活动的主要障碍。我们探讨了间歇性高强度有氧运动（IHE）是否比连续中等强度运动（CME）更能防止血糖下降，因为 IHE 旨在模拟儿童自发的身体活动模式。
5 名男孩和 7 名女孩（9.8±1.4 岁）进行基于测功计的随机 CME 和 IHE，运动持续时间和总机械负荷相同[50%PWC 与 15 秒（150%PWC）/30 秒被动恢复；均在两个 10 分钟的运动组中进行，两组之间休息 5 分钟]。与不活动状态相比，比较了运动过程中的毛细血管血糖和恢复过程中的间质血糖，并控制了基础血糖、碳水化合物和胰岛素。
与 CME 相比，IHE 使毛细血管血糖降低减少了 1.47mmol·L（P<0.05）。在运动过程中没有发生症状性低血糖发作。在两种条件下，运动后的低血糖时间没有差异。在早期恢复期间，与不活动相比，CME 降低了>16.7mmol·L 的时间（P<0.05；CME：0%；IHE：16.7%；INACTIVE：41.7%）。
与 CME 相比，IHE 似乎限制了血糖下降。与不活动相比，进行 20 分钟的 CME 或 IHE 与增加低血糖风险无关。CME 似乎甚至在短暂时间内对严重高血糖有保护作用。
