Department of Internal Medicine, University Hospital Osijek, 31000 Osijek, Croatia.
Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia.
Int J Environ Res Public Health. 2023 Mar 11;20(6):4966. doi: 10.3390/ijerph20064966.
(1) Background: The increased risk of developing hypoglycemia and worsening of glycemic stability during exercise is a major cause of concern for patients with type 1 diabetes mellitus (T1DM). (2) Aim: This pilot study aimed to assess glycemic stability and hypoglycemic episodes during and after aerobic versus resistance exercises using a flash glucose monitoring system in patients with T1DM. (3) Participants and Methods: We conducted a randomized crossover prospective study including 14 adult patients with T1DM. Patients were randomized according to the type of exercise (aerobic vs. resistance) with a recovery period of three days between a change of groups. Glucose stability and hypoglycemic episodes were evaluated during and 24 h after the exercise. Growth hormone (GH), cortisol, and lactate levels were determined at rest, 0, 30, and 60 min post-exercise period. (4) Results: The median age of patients was 53 years, with a median HbA1c of 7.1% and a duration of diabetes of 30 years. During both training sessions, there was a drop in glucose levels immediately after the exercise (0'), followed by an increase at 30' and 60', although the difference was not statistically significant. However, glucose levels significantly decreased from 60' to 24 h in the post-exercise period ( = 0.001) for both types of exercise. Glycemic stability was comparable prior to and after exercise for both training sessions. No differences in the number of hypoglycemic episodes, duration of hypoglycemia, and average glucose level in 24 h post-exercise period were observed between groups. Time to hypoglycemia onset was prolonged after the resistance as opposed to aerobic training (13 vs. 8 h, = NS). There were no nocturnal hypoglycemic episodes (between 0 and 6 a.m.) after the resistance compared to aerobic exercise (4 vs. 0, = NS). GH and cortisol responses were similar between the two sessions, while lactate levels were significantly more increased after resistance training. (5) Conclusion: Both exercise regimes induced similar blood glucose responses during and immediately following acute exercise.
(1) 背景：1 型糖尿病（T1DM）患者在运动期间发生低血糖和血糖稳定性恶化的风险增加是主要关注点。(2) 目的：本研究旨在使用瞬态血糖监测系统评估 T1DM 患者在进行有氧运动与抗阻运动期间和之后的血糖稳定性和低血糖发作情况。(3) 参与者和方法：我们进行了一项随机交叉前瞻性研究，纳入了 14 名成年 T1DM 患者。患者根据运动类型（有氧运动与抗阻运动）进行随机分组，两组之间的恢复期为 3 天。在运动期间和运动后 24 小时评估血糖稳定性和低血糖发作情况。在休息时、运动后 0、30 和 60 分钟测定生长激素（GH）、皮质醇和乳酸水平。(4) 结果：患者的中位年龄为 53 岁，中位糖化血红蛋白（HbA1c）为 7.1%，糖尿病病程为 30 年。在两种训练方案中，运动后即刻（0'）血糖水平均出现下降，随后在 30'和 60'升高，但差异无统计学意义。然而，在运动后期间（24 小时），血糖水平从 60'开始显著下降（ = 0.001）。两种训练方案的运动前后血糖稳定性相当。两组之间，运动后 24 小时内低血糖发作次数、低血糖持续时间和平均血糖水平无差异。与有氧运动相比，抗阻运动后低血糖发作时间延长（13 与 8 小时， = NS）。与有氧运动相比，抗阻运动后无夜间低血糖发作（0 至 6 点之间）（4 与 0， = NS）。两种运动方案中 GH 和皮质醇反应相似，而抗阻训练后乳酸水平显著升高。(5) 结论：两种运动方案在急性运动期间和运动后即刻均引起相似的血糖反应。
