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对脊髓脊膜膨出的宫内修复的思考。

Reflections upon the intrauterine repair of myelomeningocele.

机构信息

Dep. of Neurosurgery, ASST Niguarda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

出版信息

Childs Nerv Syst. 2024 May;40(5):1571-1575. doi: 10.1007/s00381-024-06365-0. Epub 2024 Mar 22.

DOI:10.1007/s00381-024-06365-0
PMID:38514517
Abstract

The intrauterine repair of myelomeningocele presents certain advantages and has gained widespread acceptance. It significantly reduces the incidence of Chiari-2 anomalies and hydrocephalus, and it is thought to enhance the neurologic outcome. Nevertheless, several issues remain unsettled and there are no negligible disadvantages. After working with patients with myelomeningocele for 30 years, I thought about how we currently treat them. There are ethical, organizational, neurological, obstetrical, and postnatal aspects worth discussing.

摘要

脊髓脊膜膨出的宫内修复具有一定的优势,已被广泛接受。它显著降低了 Chiari-2 畸形和脑积水的发生率,并被认为能改善神经预后。然而,仍有一些问题尚未解决,且存在不可忽视的缺点。在与脊髓脊膜膨出患者合作 30 年后,我思考了我们目前对他们的治疗方法。其中涉及伦理、组织、神经、产科和产后等方面,值得讨论。

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本文引用的文献

1
Neurologic Outcome Comparison between Fetal Open-, Endoscopic- and Neonatal-Intervention Techniques in Spina Bifida Aperta.开放性脊柱裂胎儿干预、内镜干预及新生儿干预技术的神经学结局比较
Diagnostics (Basel). 2023 Jan 9;13(2):251. doi: 10.3390/diagnostics13020251.
2
Intrauterine closure of myelomeningocele defects with primary linear repair versus bipedicle fasciocutaneous flaps: a post-MOMS cohort study with long-term follow-up.原发性线性修复与双蒂筋膜皮瓣修复在脊髓脊膜膨出缺陷宫内闭合中的应用:一项MOMS后队列长期随访研究
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3
Tethered cord release in patients after open fetal myelomeningocele closure: intraoperative neuromonitoring data and patient outcomes.
开放性胎儿脊髓脊膜膨出修补术后患者的脊髓栓系松解术:术中神经监测数据及患者预后
Childs Nerv Syst. 2023 Mar;39(3):663-670. doi: 10.1007/s00381-022-05756-5. Epub 2022 Nov 16.
4
Experience of 300 cases of prenatal fetoscopic open spina bifida repair: report of the International Fetoscopic Neural Tube Defect Repair Consortium.300 例产前经镜开放性脊柱裂修复经验:国际经镜神经管缺陷修复联盟报告。
Am J Obstet Gynecol. 2021 Dec;225(6):678.e1-678.e11. doi: 10.1016/j.ajog.2021.05.044. Epub 2021 Jun 3.
5
Open fetal surgery for myelomeningocele repair in France.法国开展的开放性胎儿脊髓脊膜膨出修复手术。
J Gynecol Obstet Hum Reprod. 2021 Nov;50(9):102155. doi: 10.1016/j.jogoh.2021.102155. Epub 2021 Apr 26.
6
Comparison of Follow-Up Length-Matched Single-Center Myelomeningocele Postnatal Closure Cohort to the Management of Myelomeningocele Study (MOMS) Trial Results.随访时长匹配的单中心脊髓脊膜膨出产后闭合队列与脊髓脊膜膨出管理研究(MOMS)试验结果的比较。
Pediatr Neurosurg. 2021;56(3):229-238. doi: 10.1159/000515038. Epub 2021 Apr 13.
7
Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial.脊髓脊膜膨出患儿的产前修复与身体机能:一项随机临床试验的二次分析。
JAMA Pediatr. 2021 Apr 1;175(4):e205674. doi: 10.1001/jamapediatrics.2020.5674. Epub 2021 Apr 5.
8
Surgical management of Chiari malformation type II.II型Chiari畸形的外科治疗
Childs Nerv Syst. 2020 Aug;36(8):1621-1634. doi: 10.1007/s00381-020-04675-7. Epub 2020 May 30.
9
Fetal surgery for open spina bifida.开放性脊柱裂的胎儿手术
Obstet Gynaecol. 2019 Oct;21(4):271-282. doi: 10.1111/tog.12603. Epub 2019 Sep 27.
10
Fetal surgery for spina bifida.脊柱裂的胎儿手术
J Neurosurg Pediatr. 2019 Aug 1;24(2):105-114. doi: 10.3171/2019.4.PEDS18383.