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开放性脊柱裂的胎儿手术

Fetal surgery for open spina bifida.

作者信息

Sacco Adalina, Ushakov Fred, Thompson Dominic, Peebles Donald, Pandya Pranav, De Coppi Paolo, Wimalasundera Ruwan, Attilakos George, David Anna Louise, Deprest Jan

机构信息

Clinical Research Fellow, Fetal Medicine Unit Elizabeth Garrett Anderson Wing University College London Hospital NHS Foundation Trust 235 Euston Road London NW1 2BU UK.

Specialist in Fetal Medicine, Fetal Medicine Unit Elizabeth Garrett Anderson Wing University College London Hospital NHS Foundation Trust 235 Euston Road London NW1 2BU UK.

出版信息

Obstet Gynaecol. 2019 Oct;21(4):271-282. doi: 10.1111/tog.12603. Epub 2019 Sep 27.

Abstract

KEY CONTENT

Spina bifida is a congenital neurological condition with lifelong physical and mental effects.Open fetal repair of the spinal lesion has been shown to improve hindbrain herniation, ventriculoperitoneal shunting, independent mobility and bladder outcomes for the child and, despite an increased risk of prematurity, does not seem to increase the risk of neurodevelopmental impairment.Open fetal surgery is associated with maternal morbidity.Surgery at our institution is offered and performed according to internationally agreed criteria and protocols.Further evidence regarding long-term outcomes, fetoscopic repair and alternative techniques is awaited.

LEARNING OBJECTIVES

To understand the clinical effects, potential prevention and prenatal diagnosis of spina bifida.To understand the rationale and evidence supporting the benefits and risks of fetal repair of open spina bifida.To understand the criteria defining those who are likely to benefit from fetal surgery.

ETHICAL ISSUES

The concept of the fetus as a patient, and issues surrounding fetal death or the need for resuscitation during fetal surgery.The associated maternal morbidity in a procedure performed solely for the benefit of the fetus/child.The financial implications of new surgical treatments.

摘要

关键内容

脊柱裂是一种先天性神经疾病,会对患者的身心造成终身影响。胎儿开放性脊柱病变修复术已被证明可改善患儿的后脑疝、脑室腹腔分流、独立活动能力及膀胱功能,尽管早产风险增加,但似乎并不会增加神经发育障碍的风险。胎儿开放性手术与母体发病相关。我们机构的手术是根据国际公认的标准和方案提供并实施的。关于长期预后、胎儿镜修复及替代技术的更多证据仍有待观察。

学习目标

了解脊柱裂的临床影响、潜在预防措施及产前诊断方法。理解支持开放性脊柱裂胎儿修复术利弊的基本原理和证据。理解界定可能从胎儿手术中获益者的标准。

伦理问题

将胎儿视为患者的概念,以及胎儿手术期间胎儿死亡或复苏需求相关问题。仅为胎儿/儿童利益实施的手术所伴随的母体发病情况。新手术治疗的经济影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e33/6876677/d99c28aabf8e/TOG-21-271-g001.jpg

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