Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Department of Molecular Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing, China.
Int J Rheum Dis. 2024 Mar;27(3):e15123. doi: 10.1111/1756-185X.15123.
To investigate the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA).
This meta-analysis study systematically retrieved relevant studies from PubMed, Embase, the Cochrane Central, Wanfang Data, CNKI, and SinoMed up to November 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP gene polymorphisms and OA.
A total of nine case-control studies comprising 1719 knee OA patients and 1904 controls were included in this meta-analysis. The results revealed that MMP-1-1607 (rs1799750) 1G/2G polymorphism was not significantly associated with knee OA risk in four genetic models (OR (95% CI): allele model: 0.89 (0.57, 1.40), p = .615); dominant mode: 0.82 (0.47, 1.44), p = .486; recessive model: 0.88 (0.49, 1.57), p = .659; homozygote model: 0.79 (0.34, 1.82), p = .576. The association was significant for dominant model of MMP-3 C/T: 1.54 (1.10-2.15), p = .013, especially in Asian ethnicity (1.63 (1.11, 2.39), p = .013). Variants of MMP-13 C/T polymorphism were associated with increased risk of knee OA development based on dominant model: 1.56 (1.19, 2.06), p = .001 and homozygote model: 2.12 (1.44, 3.13), p < .001, and there were significant associations between MMP-13 C/T polymorphism and knee OA risk in Asian ethnicity under different genetic models (all p > .05).
Present evidence suggested that the gene polymorphisms of MMP-1-1607 1G/2G may not be associated with the risk of OA. But, the dominant model of MMP-3 and MMP-13 polymorphisms in Asian ethnicity was significantly correlated with knee OA.
探讨基质金属蛋白酶（MMP）基因多态性与膝骨关节炎（OA）发病机制的关联。
本荟萃分析研究系统地检索了PubMed、Embase、Cochrane 中央、万方数据、CNKI 和 SinoMed 数据库，检索时间截至 2020 年 11 月，以评估 MMP 基因多态性与 OA 之间的关联。使用比值比（OR）和 95%置信区间（CI）来估计关联。
本荟萃分析共纳入了 9 项病例对照研究，包括 1719 例膝 OA 患者和 1904 例对照。结果显示，MMP-1-1607（rs1799750）1G/2G 多态性在四种遗传模型中均与膝 OA 风险无关（OR（95%CI）：等位基因模型：0.89（0.57，1.40），p=0.615；显性模型：0.82（0.47，1.44），p=0.486；隐性模型：0.88（0.49，1.57），p=0.659；纯合子模型：0.79（0.34，1.82），p=0.576）。MMP-3C/T 多态性的显性模型与膝骨关节炎的发生风险相关：1.54（1.10-2.15），p=0.013，尤其是在亚洲人群中（1.63（1.11，2.39），p=0.013）。MMP-13C/T 多态性的显性模型与膝 OA 的发生风险增加相关：1.56（1.19，2.06），p=0.001 和纯合子模型：2.12（1.44，3.13），p<0.001，并且 MMP-13C/T 多态性与不同遗传模型下的亚洲人群的膝 OA 风险相关（均 p>0.05）。
目前的证据表明，MMP-1-1607 1G/2G 基因多态性可能与 OA 风险无关。但是，亚洲人群中 MMP-3 和 MMP-13 多态性的显性模型与膝骨关节炎显著相关。
