Muraoka Hirotaka, Kaneda Takashi, Kondo Takumi, Otsuka Kohei, Tokunaga Satoshi
Department of Radiology, Nihon University School of Dentistry at Matsudo 2-870-1 Sakaecho-Nishi, Matsudo, Japan.
Oral Dis. 2024 Nov;30(8):5154-5159. doi: 10.1111/odi.14938. Epub 2024 Mar 21.
This study aimed to apply diffusion-weighted imaging to the evaluation of cervical lymph nodes affected by medication-related osteonecrosis of the jaw (MRONJ).
This retrospective study analysed the diffusion-weighted imaging data of 70 patients with or without MRONJ (Stages 0-3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann-Whitney test. Moreover, receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of ADC values to predict lymph nodes that were affected by MRONJ. p < 0.05 was considered statistically significant.
The median [interquartile range] (×10 mm/s) of level IB was 0.74 [0.7-0.81] and 0.93 [0.84-1.09] and that of level IIA was 0.79 [0.76-0.85] and 0.97 [0.84-1.06] in the control and MRONJ groups respectively. ROC analysis revealed that the ADC value had excellent ability to discriminate between the control and MRONJ groups.
The study findings indicate that diffusion-weighted imaging can contribute to differentiation of MRONJ from other cervical lymph node diseases and facilitate early detection of MRONJ.
本研究旨在应用扩散加权成像评估药物性颌骨坏死（MRONJ）累及的颈部淋巴结。
这项回顾性研究分析了70例有无MRONJ（0 - 3期）患者的扩散加权成像数据。计算对照组和MRONJ组下颌下（IB区）和颈内静脉上组（IIA区）淋巴结的平均表观扩散系数（ADC）值，并采用曼-惠特尼检验分析差异。此外，进行受试者操作特征（ROC）曲线分析，以评估ADC值预测受MRONJ影响淋巴结的能力。p < 0.05被认为具有统计学意义。
对照组和MRONJ组中，IB区的中位数[四分位间距]（×10⁻³mm²/s）分别为0.74[0.7 - 0.81]和0.93[0.84 - 1.09]，IIA区分别为0.79[0.76 - 0.85]和0.97[0.84 - 1.06]。ROC分析显示，ADC值具有出色的区分对照组和MRONJ组的能力。
研究结果表明，扩散加权成像有助于将MRONJ与其他颈部淋巴结疾病区分开来，并有助于早期发现MRONJ。
