Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
BMC Immunol. 2024 Mar 21;25(1):20. doi: 10.1186/s12865-024-00612-4.
The human interleukin-17 (IL-17) family comprises IL-17A to IL-17 F; their receptors are IL-17RA to IL-17RE. Evidence revealed that these cytokines can have a tumor-supportive or anti-tumor impact on human malignancies. The purpose of this study was to assess the expression of CXCR2, IL-17RA, and IL-17RC genes at the mRNA level as well as tissue and serum levels of IL-17A, vascular endothelial growth factor (VEGF), and transforming growth factor β (TGF-β) in patients with bladder cancer (BC) compared to control.
This study showed that gene expression of IL-17RA, IL-17RC, and CXCR2 in the tumoral tissue of BC patients was significantly upregulated compared with normal tissue. The findings disclosed a significant difference in the serum and tissue concentrations of IL-17A, VEGF, and TGF-β between the patient and the control groups, as well as tumor and normal tissues.
This study reveals notable dysregulation of CXCR2, IL-17RA, and IL-17RC genes, alongside changes in IL-17A, VEGF, and TGF-β levels in patients with BC than in controls. These findings indicate their possible involvement in BC development and their potential as diagnostic and therapeutic targets.
人类白细胞介素 17（IL-17）家族包括 IL-17A 至 IL-17F；其受体为 IL-17RA 至 IL-17RE。有证据表明，这些细胞因子可能对人类恶性肿瘤具有肿瘤支持或抗肿瘤的影响。本研究旨在评估膀胱癌（BC）患者与对照组相比，CXCR2、IL-17RA 和 IL-17RC 基因在 mRNA 水平以及组织和血清中 IL-17A、血管内皮生长因子（VEGF）和转化生长因子 β（TGF-β）的水平。
本研究表明，与正常组织相比，BC 患者肿瘤组织中 IL-17RA、IL-17RC 和 CXCR2 的基因表达显著上调。研究结果表明，患者组和对照组之间以及肿瘤组织和正常组织之间，血清和组织中 IL-17A、VEGF 和 TGF-β 的浓度存在显著差异。
本研究揭示了 CXCR2、IL-17RA 和 IL-17RC 基因的显著失调，以及 BC 患者中 IL-17A、VEGF 和 TGF-β 水平的变化，表明它们可能参与了 BC 的发展，具有作为诊断和治疗靶点的潜力。
