Department of Medical Biochemistry, Faculty of Medicine, Amasya University, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey.
Adv Clin Exp Med. 2024 Jul;33(7):691-698. doi: 10.17219/acem/185254.
Coronavirus disease 19 (COVID-19) is a viral infection mediated by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). The disease may affect biochemical parameters and electrolytes. C-terminal cross-linking telopeptide (CTX-I) is released during mature bone resorption and is a biomarker for predicting bone resorption.
As the pandemic progressed, understanding the effects of COVID-19 disease remained critical. Inflammatory responses triggered by the virus can result in a bone metabolism regulation imbalance. As such, this study aimed to analyze serum levels of CTX-I, calcium (CA), phosphorus (P), magnesium (Mg), C-reactive protein (CRP), and alkaline phosphatase (ALP) in COVID-19 patients to investigate the relationship between bone resorption and the disease.
The study included 56 individuals with COVID-19 (divided into mild, moderate and severe subgroups depending on disease severity) and 25 healthy adults as a control group. Serum CTX-I concentrations were measured with enzyme-linked immunosorbent assay (ELISA). In addition, CRP, Ca, Mg, P, and ALP levels were measured using an automated clinical chemistry analyzer.
Serum CTX-I levels were significantly higher in COVID-19 patients than in the control group (p < 0.05). Furthermore, a positive weak relationship was detected between CRP and CTX-I (r = 0.303, p < 0.05).
Increased serum CTX-I levels in the patient group caused COVID-19-driven bone degradation, though serum CTX-I levels did not differ according to disease severity.
新型冠状病毒病 19（COVID-19）是一种由冠状病毒-2 引起的病毒感染，可导致严重急性呼吸系统综合征（SARS-CoV-2）。该疾病可能会影响生化参数和电解质。C 端交联肽（CTX-I）在成熟骨吸收过程中释放，是预测骨吸收的生物标志物。
随着大流行的发展，了解 COVID-19 疾病的影响仍然至关重要。病毒引发的炎症反应可导致骨代谢调节失衡。因此，本研究旨在分析 COVID-19 患者的血清 CTX-I、钙（CA）、磷（P）、镁（Mg）、C 反应蛋白（CRP）和碱性磷酸酶（ALP）水平，以研究骨吸收与疾病之间的关系。
本研究纳入了 56 名 COVID-19 患者（根据疾病严重程度分为轻症、中症和重症亚组）和 25 名健康成年人作为对照组。采用酶联免疫吸附试验（ELISA）检测血清 CTX-I 浓度。此外，采用自动临床化学分析仪检测 CRP、CA、Mg、P 和 ALP 水平。
COVID-19 患者的血清 CTX-I 水平明显高于对照组（p<0.05）。此外，还检测到 CRP 与 CTX-I 之间存在微弱的正相关关系（r=0.303，p<0.05）。
患者组血清 CTX-I 水平升高导致 COVID-19 驱动的骨降解，尽管血清 CTX-I 水平与疾病严重程度无关。
