Wu Maoyuan, Zhang Wenwen, He Lianli, Zhu Ye, Jiang Xiaoling, Zhang Lixia, Yuan Xiwei, Li Tingchao
Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Department of Gynecology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Front Oncol. 2024 Mar 7;14:1298109. doi: 10.3389/fonc.2024.1298109. eCollection 2024.
Multiple primary malignant neoplasms are a rare gynecologic malignancy; particularly, cases originating from the heterologous organs, such as the ovary and cervix. Here, we report a case of two primary malignant neoplasms in a patient who had undergone laparoscopic radical hysterectomy + bilateral salpingo-oophorectomy + pelvic lymph node dissection + para-aortic lymphadenectomy + appendectomy + omentectomy + metastasectomy under general anesthesia. The patient experienced complete remission after six courses of postoperative chemotherapy with a standard Taxol and Carboplatin regimen. Genetic testing was performed to detect mutations, and poly (ADP-ribose) polymerase (PARP) inhibitors were used for maintenance therapy.
多原发性恶性肿瘤是一种罕见的妇科恶性肿瘤;特别是起源于异源器官,如卵巢和子宫颈的病例。在此,我们报告一例在全身麻醉下接受腹腔镜根治性子宫切除术+双侧输卵管卵巢切除术+盆腔淋巴结清扫术+腹主动脉旁淋巴结清扫术+阑尾切除术+大网膜切除术+转移灶切除术的患者发生双原发性恶性肿瘤的病例。该患者在接受六个疗程的标准紫杉醇和卡铂方案术后化疗后完全缓解。进行了基因检测以检测突变,并使用聚(ADP-核糖)聚合酶(PARP)抑制剂进行维持治疗。