Wang Jing, Zhao Zeqing, Yang Kai, Bai Yuxing
Department of Orthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Front Bioeng Biotechnol. 2024 Mar 7;12:1340728. doi: 10.3389/fbioe.2024.1340728. eCollection 2024.
In recent years, cell therapy has come to play an important therapeutic role in oral diseases. This paper reviews the active role of mesenchymal stem cells, immune cell sources, and other cells in oral disorders, and presents data supporting the role of cell therapy in oral disorders, including bone and tooth regeneration, oral mucosal disorders, oral soft tissue defects, salivary gland dysfunction, and orthodontic tooth movement. The paper will first review the progress of cell optimization strategies for oral diseases, including the use of hormones in combination with stem cells, gene-modified regulatory cells, epigenetic regulation of cells, drug regulation of cells, cell sheets/aggregates, cell-binding scaffold materials and hydrogels, nanotechnology, and 3D bioprinting of cells. In summary, we will focus on the therapeutic exploration of these different cell sources in oral diseases and the active application of the latest cell optimization strategies.
近年来，细胞治疗在口腔疾病中发挥着重要的治疗作用。本文综述了间充质干细胞、免疫细胞来源及其他细胞在口腔疾病中的积极作用，并展示了支持细胞治疗在口腔疾病中作用的数据，包括骨与牙再生、口腔黏膜疾病、口腔软组织缺损、唾液腺功能障碍及正畸牙移动。本文将首先综述口腔疾病细胞优化策略的进展，包括激素与干细胞联合应用、基因修饰调节细胞、细胞的表观遗传调控、细胞的药物调控、细胞片/聚集体、细胞结合支架材料与水凝胶、纳米技术以及细胞的3D生物打印。总之，我们将专注于这些不同细胞来源在口腔疾病中的治疗探索以及最新细胞优化策略的积极应用。
