Wang Lijuan, Fang Xiansong, Ling Baodian, Wang Fangsheng, Xia Yu, Zhang Wenjuan, Zhong Tianyu, Wang Xiaoling
The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China.
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Front Cell Neurosci. 2024 Mar 7;18:1359453. doi: 10.3389/fncel.2024.1359453. eCollection 2024.
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens together with the onset of neurodegenerative diseases. However, the mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which is iron-dependent, causes a specific type of cell death called ferroptosis, and there is evidence its involvement in the pathogenic cascade of neurodegenerative diseases. However, the specific mechanisms are still not well known. The present article highlights the basic processes that underlie ferroptosis and the corresponding signaling networks. Furthermore, it provides an overview and discussion of current research on the role of ferroptosis across a variety of neurodegenerative conditions.
在全球范围内，数以百万计的人受到神经退行性疾病的影响，包括亨廷顿病（HD）、肌萎缩侧索硬化症（ALS）、帕金森病（PD）和阿尔茨海默病（AD）。尽管在疾病相关研究中投入了大量的精力和资金，但治疗方法的突破仍然难以实现。细胞的破坏通常与神经退行性疾病的发作同时发生。然而，引发神经元损失的机制尚不清楚。铁依赖性的脂质过氧化会导致一种称为铁死亡的特定类型的细胞死亡，并且有证据表明其参与神经退行性疾病的致病级联反应。然而，具体机制仍不太清楚。本文重点介绍了铁死亡的基本过程以及相应的信号网络。此外，还概述并讨论了目前关于铁死亡在各种神经退行性疾病中的作用的研究。
