Galanis Petros, Katsiroumpa Aglaia, Vraka Irene, Kosiara Katerina, Siskou Olga, Konstantakopoulou Olympia, Katsoulas Theodoros, Gallos Parisis, Kaitelidou Daphne
Clinical Epidemiology Laboratory, Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece.
Department of Radiology, P. & A. Kyriakou Children's Hospital, Athens, Greece.
Acta Med Litu. 2023;30(2):139-151. doi: 10.15388/Amed.2023.30.2.6. Epub 2023 Jul 31.
Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs.
An online cross-sectional study with a convenience sample was conducted in Greece from November 2022 to January 2023. We measured the demographic and clinical characteristics of patients with post-COVID-19 dysautonomia in terms of the quality of life with the EQ-5D-3L, and anxiety and depressive symptoms by employing .
The study population included 122 patients with post-COVID-19 syndrome. One out of four patients (27.8%) manifested post-COVID-19 dysautonomia, while the mean duration of COVID-19 symptoms was 11.6 months. Anxiety and depressive symptoms were worse after the post-COVID-19 syndrome (p<0.001 in both cases). A statistically significant reduction in quality of life was observed among patients after the post-COVID-19 syndrome (p<0.001 for both EQ-5D-3L index value and EQ-5D-3L VAS). Post-COVID-19 dysautonomia increased depression symptoms after developing the post-COVID-19 syndrome (p=0.02). We found a negative relationship between the duration of COVID-19 symptoms and the quality of life (p<0.001). Moreover, our results showed that depressive symptoms were more common among females after the post-COVID-19 syndrome (p=0.01). Also, the quality of life was lower among females than males (p=0.004 for EQ-5D-3L index value, and p=0.007 for EQ-5D-3L VAS).
Our results suggest that post-COVID-19 syndrome causes a tremendous impact on the patients' quality of life and mental health. In addition, we found that the groups most psychologically affected were patients with post-COVID-19 dysautonomia, females, and patients with a longer duration of symptoms. Policy makers should assign priority rights to vulnerable groups in future psychiatric planning. Policy measures should focus on the mental health of post-COVID-19 patients who seem to be particularly vulnerable.
新冠后综合征影响着大量感染新冠病毒的个体，即使是无症状感染者也会出现多种神经和神经精神症状及体征。
2022年11月至2023年1月在希腊进行了一项采用便利抽样的在线横断面研究。我们通过EQ-5D-3L量表测量了新冠后自主神经功能障碍患者的人口统计学和临床特征，以及焦虑和抑郁症状。
研究人群包括122例新冠后综合征患者。四分之一的患者（27.8%）表现出新冠后自主神经功能障碍，而新冠症状的平均持续时间为11.6个月。新冠后综合征出现后，焦虑和抑郁症状更严重（两种情况均p<0.001）。在新冠后综合征患者中观察到生活质量有统计学意义的下降（EQ-5D-3L指数值和EQ-5D-3L视觉模拟量表均p<0.001）。新冠后自主神经功能障碍在出现新冠后综合征后增加了抑郁症状（p=0.02）。我们发现新冠症状的持续时间与生活质量之间存在负相关（p<0.001）。此外，我们的结果表明，新冠后综合征出现后，女性的抑郁症状更为常见（p=0.01）。而且，女性的生活质量低于男性（EQ-5D-3L指数值p=0.004，EQ-5D-3L视觉模拟量表p=0.007）。
我们的结果表明，新冠后综合征对患者的生活质量和心理健康产生了巨大影响。此外，我们发现受心理影响最大的群体是新冠后自主神经功能障碍患者、女性以及症状持续时间较长的患者。政策制定者在未来的精神卫生规划中应赋予弱势群体优先权利。政策措施应关注似乎特别脆弱的新冠后患者的心理健康。
