Smith H V, Kusel J R
Clin Exp Immunol. 1979 Jun;36(3):430-5.
Serum from patients suffering from the autoimmune skin disease pemphigus vulgaris has been used to demonstrate the presence of intercellular substance (ICS) on the surface of these chistosomula of Schistosoma mansoni which has penetrated mouse skin in vitro or during a percutaneous infection. ICS was absent from mechanically transformed schistosomula or those formed in the peritoneal cavity of mice. Schistosomula which penetrated mouse skin rapidly in vitro acquired very little of the ICS. It was found during a percutaneous infection that schistosomula recovered from the skin after 10 min had no detectable ICS, while those recovered after 2 hr and 24 hr gained increasing quantities of the material. It is concluded that schistosomula which are delayed in their exit from the skin acquire more ICS. However, this material must be shed during subsequent migration since schistosomula from lung and liver, and 7-week-old worms do not posses it. The implications of the findings are discussed.
患有自身免疫性皮肤病寻常型天疱疮患者的血清已被用于证明曼氏血吸虫的这些童虫表面存在细胞间物质（ICS），这些童虫已在体外穿透小鼠皮肤或在经皮感染期间穿透小鼠皮肤。机械转化的童虫或在小鼠腹腔中形成的童虫不存在ICS。在体外迅速穿透小鼠皮肤的童虫获得的ICS很少。在经皮感染期间发现，10分钟后从皮肤中回收的童虫未检测到ICS，而2小时和24小时后回收的童虫获得的该物质数量增加。得出的结论是，从皮肤中逸出延迟的童虫获得更多的ICS。然而，这种物质在随后的迁移过程中必须脱落，因为来自肺和肝的童虫以及7周龄的虫体不具有这种物质。讨论了这些发现的意义。
