Altern Ther Health Med. 2024 Nov;30(11):40-43.
Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) and Laryngopharyngeal Reflux Disease (LPRD) are interrelated medical conditions affecting the respiratory system. This article aimed to investigate the potential correlation between the two.
This cross-sectional study was carried out on a total of 52 participants diagnosed with both OSAHS and LPRD. Clinical data of baseline demographics of year, sex, BMI, including clinical indicators such as AHI (Apnea Hypopnea Index), OSAHS severity grading, RFS (Reflux Finding Score), RSI (Reflux Symptom Index), and 24-hour pH level were collected. Statistical analysis was then conducted to evaluate the correlation between OSAHS and LPRD.
Among the 52 patients, the the average age was 43.3±11.6 years with a mean 24.7±2.9 kg/m2 BMI level. The mean duration of OSAHS was 4.1±1.7 years with mean 38.7±12 AHI scores and 30.8% mild OSAHS, 51.9% moderate OSAHS, and 17.3% severe OSAHS. Mean LPRD duration was 3.2±1.5 years with a mean 15.9±4.9 RFS score, mean 28.0±6.8 RSI score, and mean 3.9±0.8 24-hour pH level. There was a strong positive correlation between AHI scores and both the RFS score (r>0.9, P < .01) and RSI score (r>0.9, P < .01). While a strong negative correlation between AHI scores and 24-hour pH level was observed (r < -0.8, P < .01). And there was a strong positive correlation between OSAHS severity levels and both the RSF score (r>0.8, P < .01) and RSI score (r>0.79, P < .01). While a significant negative correlation between OSAHS severity and 24-hour pH level was detected (r < -0.7, P < .01).
The findings of this cross-sectional study demonstrate a strong positive correlation between the severity of OSAHS, as indicated by AHI scores, and the severity of LPRD, as measured by RFS and RSI scores. A negative correlation was also observed between AHI scores and 24-hour pH level, indicating a connection between these two medical conditions.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）和喉咽反流病（LPRD）是相互关联的影响呼吸系统的医学病症。本文旨在探讨这两种病症之间的潜在关联。
本研究采用横断面研究方法，共纳入 52 名同时诊断为 OSAHS 和 LPRD 的患者。收集患者的基本人口统计学数据（年龄、性别、BMI），包括临床指标，如呼吸暂停低通气指数（AHI）、OSAHS 严重程度分级、反流发现评分（RFS）、反流症状指数（RSI）和 24 小时 pH 值。然后进行统计学分析，以评估 OSAHS 和 LPRD 之间的相关性。
52 名患者的平均年龄为 43.3±11.6 岁，平均 BMI 为 24.7±2.9kg/m2。OSAHS 的平均病程为 4.1±1.7 年，平均 AHI 评分为 38.7±12，轻度 OSAHS 占 30.8%，中度 OSAHS 占 51.9%，重度 OSAHS 占 17.3%。LPRD 的平均病程为 3.2±1.5 年，平均 RFS 评分为 15.9±4.9，平均 RSI 评分为 28.0±6.8，平均 24 小时 pH 值为 3.9±0.8。AHI 评分与 RFS 评分（r>0.9，P<0.01）和 RSI 评分（r>0.9，P<0.01）之间呈强正相关。而 AHI 评分与 24 小时 pH 值之间呈强负相关（r<-0.8，P<0.01）。OSAHS 严重程度与 RSF 评分（r>0.8，P<0.01）和 RSI 评分（r>0.79，P<0.01）之间呈强正相关。而 OSAHS 严重程度与 24 小时 pH 值之间呈显著负相关（r<-0.7，P<0.01）。
本横断面研究结果表明，OSAHS 的严重程度与 LPRD 的严重程度之间存在很强的正相关，这种相关性由 AHI 评分来衡量，同时，AHI 评分与 24 小时 pH 值之间呈负相关，这表明这两种病症之间存在关联。
