Rzayeva Gunay, Kale İbrahim, Arısoy Resul, Muhcu Murat
Obstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Faculty of Medicine, Department of Obstetrics and Gynecology, Usküdar University, Istanbul, Turkey.
Z Geburtshilfe Neonatol. 2024 Dec;228(6):514-519. doi: 10.1055/a-2271-1198. Epub 2024 Mar 22.
To investigate the fetal breathing-related nasal fluid flow Doppler waveforms as an indicator of fetal respiratory function in fetuses diagnosed with fetal growth restriction (FGR) in the third trimester.
This prospective, non-interventional case-control study was conducted on 96 pregnant women, including 23 pregnant women diagnosed with FGR in the third trimester as the FGR group and 73 healthy pregnant women with fetuses appropriate for gestational age (AGA) as the control group. Fetal breathing-related nasal fluid flow Doppler was examined in the fetuses of the participants. Inspiration and expiration duration, inspiration and expiration peak velocity, total breathing duration, and number of fetal breaths per minute were calculated.
Both groups were similar in terms of the duration of inspiration, duration of expiration, and total breathing duration (p=0.463, p=0.711, p=0.520, respectively). Peak inspiratory velocity and peak expiratory velocity were significantly lower in the FGR group than in the control group, and the number of fetal breaths per minute was similar in both groups (p=0.027, p=0.012, p=0.768, respectively). When participants were regrouped into those whose newborn was admitted to the neonatal intensive care unit (NICU) after birth and those who were not, all fetal nasal fluid flow Doppler parameters were similar in both groups.
Although the number of participants was too small to draw a definitive conclusion, FGR appears to be associated with a decrease in peak inspiratory and expiratory velocity. The clinical significance of changes in fetal breathing-related nasal fluid flow Doppler parameters in FGR is as yet unclear, and their use in clinical follow-up and predicting unfavorable perinatal outcomes are the subjects of future research.
研究孕晚期诊断为胎儿生长受限（FGR）的胎儿与呼吸相关的鼻腔液体流动多普勒波形，作为胎儿呼吸功能的指标。
本前瞻性、非干预性病例对照研究对96名孕妇进行，其中包括23名孕晚期诊断为FGR的孕妇作为FGR组，73名胎儿孕周适宜的健康孕妇作为对照组。对参与者的胎儿进行与呼吸相关的鼻腔液体流动多普勒检查。计算吸气和呼气持续时间、吸气和呼气峰值流速、总呼吸持续时间以及每分钟胎儿呼吸次数。
两组在吸气持续时间、呼气持续时间和总呼吸持续时间方面相似（分别为p = 0.463、p = 0.711、p = 0.520）。FGR组的吸气峰值流速和呼气峰值流速显著低于对照组，两组的每分钟胎儿呼吸次数相似（分别为p = 0.027、p = 0.012、p = 0.768）。当将参与者重新分为出生后新生儿入住新生儿重症监护病房（NICU）的和未入住的两组时，两组所有胎儿鼻腔液体流动多普勒参数相似。
尽管参与者数量过少无法得出明确结论，但FGR似乎与吸气和呼气峰值流速降低有关。FGR中与呼吸相关的鼻腔液体流动多普勒参数变化的临床意义尚不清楚，其在临床随访和预测不良围产期结局中的应用是未来研究的课题。
