揭示母体妊娠期糖尿病对脐带血CD71+红系细胞转录组的影响。
Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome.
作者信息
Yin Min, Zhang Yan, Li Xinyu, Li Xia
机构信息
National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
出版信息
Pediatr Res. 2024 Jul;96(2):309-312. doi: 10.1038/s41390-024-03139-x. Epub 2024 Mar 22.
This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood. It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring. This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.
本研究揭示了母亲妊娠期糖尿病（GDM）对脐血中CD71+红系细胞（CECs）转录组的影响。它突出了CECs在免疫抑制功能中的作用，并确定了将GDM与后代不良结局联系起来的潜在机制。这种认识可能会带来改进的策略，用于管理和预防GDM母亲所生婴儿的不良结局。
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