Department of Otorhinolaryngology, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Department of Community and Family Medicine, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Eur Arch Otorhinolaryngol. 2024 Aug;281(8):4241-4254. doi: 10.1007/s00405-024-08557-5. Epub 2024 Mar 23.
This cross-sectional study aimed to establish normative values for Sino-Nasal Outcome Test (SNOT-22) score in adult Indian population without known sino-nasal diseases. The purpose was to fill a critical knowledge gap, providing insights into how various host factors influence SNOT-22 scores which seek to serve as reference for clinical studies, facilitating comparisons of symptom severity and aid in patient counselling based on specific score patterns.
One thousand and twelve adults meeting inclusion criteria participated in the study. Participants provided demographic information, occupation details, addiction history, and medical background. They completed SNOT-22 questionnaire, grading their symptoms on Likert scale of 0-5 based on severity experienced in the past 2 weeks. The collected data were analysed to derive meaningful insights.
Mean SNOT-22 score for the study population was 6.80, with 90% scoring below 15, and 40% within 0-3 range. Females exhibited significantly lower mean scores than males. Residents of rural areas reported higher scores than urban counterparts. Education levels had no significant influence on scores. Occupational exposure to aeroallergens, addiction (especially tobacco), and a history of allergies, bronchial asthma, or atopy were associated with significantly higher SNOT-22 scores. Principal component analysis identified four distinct domains, with the nasal symptom domain consistently emerging as the major contributor to differences in subgroups with significantly different total SNOT-22 scores.
The normative data and subgroup analyses established in this study serve as a foundation for future research, aiding clinicians in predicting symptoms and providing tailored counselling for individuals with sino-nasal pathologies.
本横断面研究旨在为无已知鼻-鼻窦疾病的印度成年人群建立 Sino-Nasal Outcome Test（SNOT-22）评分的正常值。目的是填补一个关键的知识空白，深入了解各种宿主因素如何影响 SNOT-22 评分，为临床研究提供参考，便于比较症状严重程度，并根据特定的评分模式为患者提供咨询。
符合纳入标准的 112 名成年人参与了这项研究。参与者提供了人口统计学信息、职业细节、成瘾史和医疗背景。他们完成了 SNOT-22 问卷，根据过去 2 周内经历的严重程度，在 0-5 的李克特量表上对症状进行评分。收集的数据进行了分析，以得出有意义的见解。
研究人群的平均 SNOT-22 评分为 6.80，90%的评分低于 15，40%的评分在 0-3 范围内。女性的平均得分明显低于男性。农村地区的居民报告的得分高于城市居民。教育水平对评分没有显著影响。职业性接触气源性过敏原、成瘾（尤其是烟草）以及过敏、支气管哮喘或特应性的病史与 SNOT-22 评分显著升高相关。主成分分析确定了四个不同的领域，其中鼻腔症状领域始终是总 SNOT-22 评分存在显著差异的亚组之间差异的主要贡献者。
本研究建立的正常值和亚组分析为未来的研究提供了基础，有助于临床医生预测症状，并为鼻-鼻窦疾病患者提供个性化的咨询。
