Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St. Box 357470, Seattle, WA, USA; Fred Hutchinson Cancer Center, Clinical Research Division, 1100 Fairview Avenue N., Seattle, WA 98109, USA.
Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St. Box 357470, Seattle, WA, USA.
Cancer Genet. 2024 Jun;284-285:30-33. doi: 10.1016/j.cancergen.2024.03.001. Epub 2024 Mar 16.
The WHO classifications of hematolymphoid malignancies have recognized several distinct entities within the large B cell lymphomas, including the more recently described high-grade B cell lymphoma with 11q aberration (HGBCL-11q). We utilized genomic array to assess for chromosome 11q abnormalities in a broad set of aggressive B cell lymphomas from 27 patients with a focus on younger adults. The findings suggest more frequent alterations of 11q in diffuse large B cell lymphoma (DLBCL)/HGBCL-GC BCL2-, in comparison to cases of Burkitt lymphoma (BL) or DLBCL-GC BCL2+, and confirm a low genomic complexity score of BL. Variability identified in patterns of 11q alterations suggests genomic array studies may afford value over FISH testing as we continue to understand HGBCL-11q as a distinct entity, and interrogate cases of DLBCL/HGBCL-GC BCL2-.
世界卫生组织（WHO）对血液淋巴组织肿瘤的分类在大型 B 细胞淋巴瘤中已确认了几种不同的实体，包括最近描述的具有 11q 异常的高级别 B 细胞淋巴瘤（HGBCL-11q）。我们利用基因组芯片在 27 例以年轻患者为主的侵袭性 B 细胞淋巴瘤中广泛评估染色体 11q 异常。研究结果表明弥漫性大 B 细胞淋巴瘤（DLBCL）/HGBCL-GC BCL2-中 11q 的改变更为频繁，与伯基特淋巴瘤（BL）或 DLBCL-GC BCL2+相比，证实了 BL 的基因组复杂度评分较低。11q 改变模式的可变性表明，随着我们继续将 HGBCL-11q 作为一种独特的实体进行研究，并探讨 DLBCL/HGBCL-GC BCL2-病例，基因组芯片研究可能比 FISH 检测更有价值。
