Li Hongxia, Lai Yunqi
Zhejiang Rehabilitation Hospital, Three Rehabilitation Areas/Rehabilitation Zone 3, Hangzhou, Zhejiang Province, China.
J Med Biochem. 2025 Aug 21;44(5):994-1002. doi: 10.5937/jomb0-55968.
Acute ischemic stroke (AIS) often leads to hemiplegia, significantly impairing neurological function, motor ability, and daily life activities. Early precision exercise rehabilitation has emerged as a promising intervention to enhance recovery. This study evaluated its effectiveness in improving neurological function, gait performance, and self-care ability and reducing inflammatory response in hemiplegic patients.
This retrospective cohort study included 230 patients with hemiplegia due to AIS, admitted within 72 hours of onset. Patients were divided into an Early Rehabilitation Group (EG, n = 132) and a Conventional Rehabilitation Group (CG, n = 98) based on the intervention received. The EG underwent early precision exercise rehabilitation, integrating neurofunctional training, motor-evoked potential (MEP) therapy, and functional electrical stimulation (FES), while the CG received traditional rehabilitation. The effectiveness was assessed using the National Institutes of Health Stroke Scale (NIHSS), Wisconsin Gait Scale (WGS), and Activities of Daily Living (ADL) scores. Serum inflammatory markers (TNF-a, hs-CRP IL-6, IL-18) were also measured before and after treatment.
The EG demonstrated significantly more significant improvements in NIHSS (5.85± 1.31 vs 7.03± 2.54, P< 0.05), WGS (24.81± 3.06 vs. 31 .96 ± 4.62 , P< 0.05), and ADL scores (63.08± 4.93 vs. 51 .78 ± 6.34 , P< 0.05) compared to the CG. Walking frequency and speed were also higher in the EG (P< 0.05). Inflammatory markers significantly decreased post-treatment in the EG (TNF-a: P< 0.05, hs-CRP: P< 0.05, IL-6: P< 0.05, IL-18: P< 0.05), suggesting a reduction in systemic inflammation.
Early precision exercise rehabilitation significantly enhances neurological function, motor ability, and self-care capacity, reducing inflammatory response in hemiplegic AIS patients. These findings support its integration into clinical stroke rehabilitation protocols.
急性缺血性卒中（AIS）常导致偏瘫，严重损害神经功能、运动能力和日常生活活动。早期精准运动康复已成为一种有前景的促进恢复的干预措施。本研究评估了其在改善偏瘫患者神经功能、步态表现和自我护理能力以及减轻炎症反应方面的有效性。
这项回顾性队列研究纳入了230例因AIS导致偏瘫且在发病72小时内入院的患者。根据接受的干预措施，患者被分为早期康复组（EG，n = 132）和传统康复组（CG，n = 98）。EG组接受早期精准运动康复，包括神经功能训练、运动诱发电位（MEP）治疗和功能性电刺激（FES），而CG组接受传统康复治疗。使用美国国立卫生研究院卒中量表（NIHSS）、威斯康星步态量表（WGS）和日常生活活动（ADL）评分评估有效性。治疗前后还测量了血清炎症标志物（TNF-a、hs-CRP、IL-6、IL-18）。
与CG组相比，EG组在NIHSS评分（5.85±1.31 vs 7.03±2.54，P<0.05）、WGS评分（24.81±3.06 vs 31.96±4.62，P<0.05）和ADL评分（63.08±4.93 vs 51.78±6.34，P<0.05）方面有更显著的改善。EG组的步行频率和速度也更高（P<0.05）。EG组治疗后炎症标志物显著降低（TNF-a：P<0.
