RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic; Jožef Stefan Institute, Department of Environmental Sciences, Ljubljana, Slovenia.
Oniris, INRAE, LABERCA, 44300 Nantes, France.
Environ Int. 2024 Apr;186:108585. doi: 10.1016/j.envint.2024.108585. Epub 2024 Mar 17.
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.
环境和人类群体所承受的化学负担正在增加。因此，监管风险评估必须跟上步伐，以管理、减少和预防与危险化学品相关的对人类和环境健康的不利影响。需要对已知的、新出现的或潜在未来关注的化学品进行监测，进入环境-食品-人类连续体，从一个健康的角度记录化学品对生态系统和人类健康构成的风险的现实，为早期预警系统提供信息，并支持减轻暴露风险的公共政策和安全及可持续的设计策略。在环境和人体监测计划中使用非传统的采样策略，并整合全扫描、高分辨率质谱和基于效应的分析，有可能增强对已知的、新出现的或潜在未来关注的更广泛的化学品的筛选和识别。在这里，我们概述了在欧洲化学品风险评估伙伴关系（PARC）项目中确定的关键需求和建议，以利用这些创新方法来支持下一代化学风险评估的发展。
