生长分化因子 15：炎症与心血管疾病之间的联系。

Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease.

机构信息

Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest H-1122, Hungary.

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary.

出版信息

Biomed Pharmacother. 2024 May;174:116475. doi: 10.1016/j.biopha.2024.116475. Epub 2024 Mar 24.

DOI:10.1016/j.biopha.2024.116475

PMID:38522236

Abstract

Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD. Thus, GDF-15 is a promising biomarker and potential therapeutic target for atherosclerotic CVD.

摘要

与年龄相关的疾病与衰老细胞的积累密切相关。衰老相关分泌表型（SASP）维持并促进慢性炎症，而慢性炎症与细胞和组织功能障碍有关。SASP 相关的生长和分化因子-15（GDF-15）是一种免疫调节细胞因子，与衰老有关，因此可能在动脉粥样硬化（CVD 的主要病因）的发生和维持中起调节作用。尽管 GDF-15 的作用具有组织特异性，并取决于炎症等微环境变化，但现有数据表明，GDF-15 在 CVD 中具有重要作用。因此，GDF-15 是动脉粥样硬化性 CVD 的有前途的生物标志物和潜在治疗靶点。