Dang Thuong Huyen Thi, Tran Tai Ngoc, Xing Frank, Ha Uyen Le Ngoc, Vo Khang Chung Ngoc, Nguyen Thanh Vinh, Nguyen Khang Vinh, Le Hien Thi, Truong Daniel
Movement Disorder Unit, Neurology Department, University Medical Center HCMC, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
The Truong Neurosciences Institute, Parkinson and Movement Disorder Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA 92708, USA.
J Neurol Sci. 2024 Apr 15;459:122958. doi: 10.1016/j.jns.2024.122958. Epub 2024 Mar 12.
The Vietnamese Smell Identification Test (VSIT) has been validated in determining olfactory dysfunction in the Vietnamese population; however, its value in diagnosing Parkinson's disease (PD) has not been established.
This case-control study was conducted at University Medical Center HCMC, Ho Chi Minh City, Vietnam. The study sample included non-demented PD patients and healthy controls (HC) who were gender- and age-matched. All participants were evaluated for odor identification ability using the VSIT and the Brief Smell Identification Test (BSIT).
A total of 218 HCs and 218 PD patients participated in the study. The median VSIT and BSIT scores were significantly different between PD and HC groups (VSIT, 5 (3) vs. 9 (2), P < 0.0001; BSIT, 6 (3) vs 8 (2), P < 0.0001). Using the cut-off of <8 for correct answers out of 12 odorants, the VSIT had higher sensitivity (84.4%) and specificity (86.2%) than those of the BSIT (sensitivity of 81.7% and specificity of 69.3%) for the diagnosis of PD. The area under the curve (AUC) value was greater for the VSIT than for the BSIT (0.909 vs 0.818). The smell identification scores were not significantly correlated with disease duration, disease severity, or LEDD (all p > 0.05).
The VSIT can be a valuable ancillary tool for supporting the diagnosis of PD in Vietnam. Olfactory dysfunction in PD was unrelated to the disease duration and severity. The VSIT can be applied to improve the accuracy of clinical PD diagnosis.
越南嗅觉识别测试（VSIT）已被验证可用于确定越南人群中的嗅觉功能障碍；然而，其在诊断帕金森病（PD）方面的价值尚未确立。
本病例对照研究在越南胡志明市的大学医学中心进行。研究样本包括年龄和性别匹配的非痴呆型PD患者和健康对照（HC）。所有参与者均使用VSIT和简易嗅觉识别测试（BSIT）评估气味识别能力。
共有218名HC和218名PD患者参与了研究。PD组和HC组的VSIT和BSIT中位数得分存在显著差异（VSIT，5（3）对9（2），P < 0.0001；BSIT，6（3）对8（2），P < 0.0001）。对于12种气味剂，以正确答案<8分为临界值，VSIT在诊断PD时的敏感性（84.4%）和特异性（86.2%）高于BSIT（敏感性为81.7%，特异性为69.3%）。VSIT的曲线下面积（AUC）值大于BSIT（0.909对0.818）。气味识别得分与疾病持续时间、疾病严重程度或左旋多巴等效剂量均无显著相关性（所有p > 0.05）。
VSIT可作为支持越南PD诊断的有价值辅助工具。PD中的嗅觉功能障碍与疾病持续时间和严重程度无关。VSIT可用于提高临床PD诊断的准确性。
