Chang Le, Goff H Douglas, Ding Chao, Liu Qiang, Zhao Siqi, Tao Tingting, Lu Rongxin, Gao Ying, Wu Haijing, Guo Liping
College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety, Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, No. 3 Wenyuan Road, Nanjing, Jiangsu 210023, China.
Department of Food Science, University of Guelph, Guelph N1H 6J2, ON, Canada.
Int J Biol Macromol. 2024 May;266(Pt 1):131121. doi: 10.1016/j.ijbiomac.2024.131121. Epub 2024 Mar 22.
In our aging society, dysphagia and malnutrition are growing concerns, necessitating intervention. Liquid nutrition support offers a practical solution for traditional dietary issues, but it raises a key issue: the potential for post-meal glucose spikes impacting efficacy. This study examined the effects of supplementation of Polygonatum cyrtonema Hua polysaccharide (PCP), konjac glucomannan (KGM) and their combination on acute phase postprandial glycemic response and long-term glucose metabolism in T2DM mice on a complete nutritional liquid diet. KGM was more effective in reducing postprandial glucose response, while PCP was more prominent in ameliorating long-term glucose metabolism. The KGM-PCP combination demonstrated superior outcomes in fasting blood glucose, insulin, and glucose homeostasis. PCP and KGM also influenced the composition and abundance of the gut microbiome, with the H-PCP group showing optimal performance. Moreover, the KGM-PCP combination improved body weight, lipid homeostasis, and liver health the most. PCP potentially regulates glycemia through metabolic pathways, while KGM improves glycemic metabolism by reducing postprandial glucose levels in response to viscous intestinal contents. This research identifies the structure, viscosity properties, and hypoglycemic effects of KGM and PCP in complete nutritional liquid diet fed T2DM mice, enabling their strategic utilization as hypoglycemic components in nutritional administration and glycemic regulation.
在我们这个老龄化社会中，吞咽困难和营养不良日益受到关注，需要进行干预。液体营养支持为传统饮食问题提供了一种切实可行的解决方案，但它引发了一个关键问题：餐后血糖峰值可能会影响其功效。本研究考察了黄精多糖（PCP）、魔芋葡甘聚糖（KGM）及其组合对完全营养液体饮食的2型糖尿病小鼠餐后急性期血糖反应和长期葡萄糖代谢的影响。KGM在降低餐后血糖反应方面更有效，而PCP在改善长期葡萄糖代谢方面更显著。KGM-PCP组合在空腹血糖、胰岛素和葡萄糖稳态方面表现出更优的结果。PCP和KGM还影响肠道微生物群的组成和丰度，其中H-PCP组表现最佳。此外，KGM-PCP组合对体重、脂质稳态和肝脏健康的改善最为明显。PCP可能通过代谢途径调节血糖，而KGM则通过响应肠道内容物的粘性降低餐后血糖水平来改善血糖代谢。本研究确定了KGM和PCP在完全营养液体饮食喂养的2型糖尿病小鼠中的结构、粘性特性和降血糖作用，使其能够作为营养给药和血糖调节中的降血糖成分进行策略性应用。
