State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang) , Nanchang University , 235 Nanjing East Road , Nanchang , Jiangxi 330047 , People's Republic of China.
J Agric Food Chem. 2019 May 8;67(18):5278-5288. doi: 10.1021/acs.jafc.9b01192. Epub 2019 Apr 12.
Diabetes and its complications are one of the most concerned metabolic diseases worldwide and threaten human health severely. Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on high-fat diet and streptozocin-induced type 2 diabetic rats were evaluated in this study. Administration of konjac glucomannan significantly decreased the levels of fasting blood glucose, serum insulin, glucagon-like peptide 1, and glycated serum protein. The concentrations of serum lipids, including total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, and non-esterified fatty acid, were notably reduced by konjac glucomannan treatment. In addition, antioxidant capacity, pancreatic injury, and adipose cell hypertrophy were ameliorated by konjac glucomannan administration in type 2 diabetic rats. Besides, ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based lipidomics analysis was used to explore the improvement of lipid metabolic by konjac glucomannan treatment. The disturbance of glycerolipid (diacylglycerol, monoacylglycerol, and triacylglycerol), fatty acyl (acylcarnitine and hydroxyl fatty acid), sphingolipid (ceramide and sphingomyelin), and glycerophospholipid (phosphatidylcholine) metabolism were attenuated by the glucomannan treatment. This study provided new insights for investigating the anti-diabetic effects of konjac glucomannan and suggests that konjac glucomannan may be a promising nutraceutical for treating type 2 diabetes.
糖尿病及其并发症是全球最受关注的代谢性疾病之一，严重威胁人类健康。本研究评价了魔芋葡甘聚糖对高脂饮食和链脲佐菌素诱导的 2 型糖尿病大鼠的降血糖、降血脂作用。结果表明，魔芋葡甘聚糖可显著降低空腹血糖、血清胰岛素、胰高血糖素样肽 1 和糖化血清蛋白水平。魔芋葡甘聚糖还可显著降低血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇和非酯化脂肪酸等血脂浓度。此外，魔芋葡甘聚糖可改善 2 型糖尿病大鼠的抗氧化能力、胰腺损伤和脂肪细胞肥大。同时，采用基于超高效液相色谱-四极杆飞行时间质谱的脂质组学分析方法，探讨了魔芋葡甘聚糖治疗对脂代谢的改善作用。结果表明，魔芋葡甘聚糖可减轻甘油磷脂（二酰基甘油、单酰基甘油和三酰基甘油）、脂肪酸（酰基肉碱和羟基脂肪酸）、鞘脂（神经酰胺和鞘磷脂）和甘油磷脂（磷脂酰胆碱）代谢紊乱。本研究为研究魔芋葡甘聚糖的抗糖尿病作用提供了新的思路，并表明魔芋葡甘聚糖可能是治疗 2 型糖尿病的有前途的营养保健品。
