Stryhn Josephine, Rosendahl Amalie, Juhl Carsten B, Thomsen Thordis, Brandstrup Birgitte, Møller Ann M
University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Department of Anaesthesiology, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2024 Jul;68(6):852-856. doi: 10.1111/aas.14412. Epub 2024 Mar 24.
Chronic postsurgical pain (CPSP) presents a considerable healthcare challenge, impacting patients, and healthcare providers, particularly in the context of gastrointestinal surgery. The notable incidence of CPSP in this specific surgical domain emphasizes the need to identify patients with a high risk of developing this condition. Despite various studies exploring this topic, a comprehensive systematic review focusing on prognostic factors of CPSP following gastrointestinal surgery is currently lacking. Therefore, the aim of this systematic review is, through systematically examination of existing literature, to assess both established and potentially novel prognostic factors, associated with CPSP following gastrointestinal surgery.
Adhering to the Cochrane Handbook and the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) checklist, we will use pre-established criteria based on Population, Intervention, Comparator, Outcome, Timing, and Setting (PICOT-S), to determine eligibility for inclusion. Essentially, this entails studies reporting on prognostic factors of CPSP following gastrointestinal surgery. Relevant studies will be identified through systematic searches in medical databases, examination of reference lists from included studies, and screening of Clinicaltrials.gov. No restrictions will be imposed regarding language, publication time or source, and both randomized trials and observational studies will be included. Data extraction will follow the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of prognostic factor studies (CHARMS-PF) and for quality assessment, we will use the Quality in Prognosis Studies (QUIPS) tool.
The aim for the systematic review is to identify and assess the prognostic value of potential factors for the development of CPSP following gastrointestinal surgery.
By creating a comprehensive overview of important prognostic factors for the development of CPSP following gastrointestinal surgery, the findings of this systematic review have the potential to guide future research and to enhance patient information resources.
慢性术后疼痛（CPSP）带来了相当大的医疗挑战，影响着患者和医疗服务提供者，尤其是在胃肠外科手术领域。CPSP在这一特定手术领域的显著发病率凸显了识别有发生这种情况高风险患者的必要性。尽管有各种研究探讨了这个话题，但目前缺乏一项聚焦于胃肠外科手术后CPSP预后因素的全面系统评价。因此，本系统评价的目的是通过系统审查现有文献，评估与胃肠外科手术后CPSP相关的既定和潜在的新预后因素。
遵循Cochrane手册和系统评价与Meta分析方案的首选报告项目（PRISMA-P）清单，我们将使用基于人群、干预措施、对照、结局、时间和环境（PICOT-S）的预先设定标准来确定纳入资格。本质上，这需要研究报告胃肠外科手术后CPSP的预后因素。将通过在医学数据库中进行系统检索、检查纳入研究的参考文献列表以及筛选Clinicaltrials.gov来识别相关研究。对语言、发表时间或来源不设限制，随机试验和观察性研究都将纳入。数据提取将遵循预后因素研究系统评价的关键评估和数据提取清单（CHARMS-PF），对于质量评估，我们将使用预后研究质量（QUIPS）工具。
本系统评价的目的是识别和评估胃肠外科手术后发生CPSP的潜在因素的预后价值。
通过全面概述胃肠外科手术后发生CPSP的重要预后因素，本系统评价的结果有可能指导未来的研究并加强患者信息资源。
