Department of Anaesthesiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2025 Jan;69(1):e14560. doi: 10.1111/aas.14560.
Chronic postsurgical pain (CPSP) has a great impact on quality of life and socioeconomic status. The mechanisms behind CPSP remain poorly understood, however type of surgical intervention seems to play a role. Gastrointestinal surgeries are common procedures, yet research in CPSP following gastrointestinal surgery is limited. The objective of this scoping review was to map the current literature on CPSP following gastrointestinal surgery, identifying how CPSP have been investigated, and which evidence gaps exist.
This scoping review followed a pre-published protocol and PRISMA-ScR guidelines. A search was carried out in Medline, Embase, CINAHL, Cochrane Central, Clinicaltrials.Gov, and Google Scholar. Eligible studies were original studies involving adults, undergoing gastrointestinal surgery, who had a pain assessment ≥30 days postoperatively. A two-phase screening process and data charting were done by two independent reviewers.
A total of 53 studies were included, published between 2001 and 2024, predominantly across Europe and Asia. The range of CPSP prevalence reported was 3.3%-46.1%. Only half the studies clearly defined CPSP, and the timing and manner of pain assessment varied considerably. Twenty-seven studies assessed risk factors for developing CPSP: preoperative pain and acute postoperative pain were consistently significant.
There was a wide consensus on CPSPs' negative impact on quality of life. CPSP following gastrointestinal surgery is prevalent and significantly impacts quality of life. Standardized definitions and methodologies to improve the comparability and reliability of the findings across studies are needed. Future research should focus on CPSP following specific surgical procedures to develop tailored prevention and treatment strategies.
慢性术后疼痛（CPSP）对生活质量和社会经济状况有重大影响。然而，CPSP 的发病机制仍知之甚少，但手术干预的类型似乎起着一定的作用。胃肠道手术是常见的手术，但胃肠道手术后 CPSP 的研究有限。本综述的目的是绘制胃肠道手术后 CPSP 的文献图谱，确定 CPSP 的研究方法，并确定存在哪些证据空白。
本综述遵循预先发表的方案和 PRISMA-ScR 指南。在 Medline、Embase、CINAHL、Cochrane 中心、Clinicaltrials.gov 和 Google Scholar 中进行了检索。符合条件的研究是涉及成年人的原始研究，他们接受了胃肠道手术，并且术后疼痛评估≥30 天。两名独立的审查员进行了两阶段的筛选过程和数据图表。
共纳入 53 项研究，发表时间为 2001 年至 2024 年，主要来自欧洲和亚洲。报告的 CPSP 患病率范围为 3.3%-46.1%。只有一半的研究明确界定了 CPSP，且疼痛评估的时间和方式差异很大。27 项研究评估了发展为 CPSP 的危险因素：术前疼痛和急性术后疼痛始终是显著的。
人们普遍认为 CPSP 对生活质量有负面影响。胃肠道手术后 CPSP 普遍存在，并显著影响生活质量。需要标准化的定义和方法，以提高研究之间发现的可比性和可靠性。未来的研究应集中于特定手术程序后的 CPSP，以制定有针对性的预防和治疗策略。
