简化血栓炎症评分作为心力衰竭患者全因死亡率的新型预测指标：一项回顾性队列研究
The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study.
作者信息
Cheng Meng-Die, Zheng Ying-Ying, Zhang Xing-Yan, Ruzeguli Tuersun, Sureya Yisimayili, Didaer Yisha, Ailiman Mahemuti, Zhang Jin-Ying
机构信息
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.
出版信息
J Inflamm Res. 2024 Mar 20;17:1845-1855. doi: 10.2147/JIR.S452544. eCollection 2024.
BACKGROUND
The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF).
METHODS
A total of 3741 patients were analyzed in this study. The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet count (MPV/PC) ratio at admission. The mean follow-up time was 22.75 months. Multivariable Cox regression analyses were used to investigate the associations between the sTIPS and all-cause mortality (ACM).
RESULTS
In the whole study population, multivariate Cox regression analysis showed that patients in both the sTIPS 2 and sTIPS 1 groups had significantly increased risk of ACM as compared with patients in the sTIPS 0 group (hazard ratio [HR]=1.706, 95% confidence interval [CI]: 1.405-2.072, P<0.001 and HR = 1.431, 95% CI 1.270-1.612, P<0.001). The same significant trend was observed in heart failure with preserved ejection fraction (HFpEF) patients (sTIPS1 vs sTIPS0: HR = 1.366, 95% CI 1.100-1.697, P = 0.005; sTIPS2 vs sTIPS0: HR = 1.995, 95% CI 1.460-2.725, P<0.001). However, only sTIPS 1 group had a significantly increased the risk of ACM compared to the sTIPS 0 group among patients with HFmrEF (sTIPS1 vs sTIPS0: HR = 1.648, 95% CI 1.238-2.194, P = 0.001) and HFrEF (sTIPS1 vs sTIPS0: HR = 1.322, 95% CI 1.021-1.712, P = 0.035).
CONCLUSION
sTIPS is useful in predicting risk for long-term mortality in patients with HF.
背景
简化血栓炎症评分（sTIPS）最近作为一种新的预后评分方法出现。因此，我们研究了sTIPS对预测心力衰竭（HF）患者长期死亡率的预后价值。
方法
本研究共分析了3741例患者。sTIPS是根据入院时的白细胞计数（WBC）和平均血小板体积与血小板计数（MPV/PC）之比计算得出的。平均随访时间为22.75个月。采用多变量Cox回归分析来研究sTIPS与全因死亡率（ACM）之间的关联。
结果
在整个研究人群中，多变量Cox回归分析显示，与sTIPS 0组患者相比，sTIPS 2组和sTIPS 1组患者的ACM风险显著增加（风险比[HR]=1.706，95%置信区间[CI]：1.405 - 2.072，P<0.001；HR = 1.431，95% CI 1.270 - 1.612，P<0.001）。在射血分数保留的心力衰竭（HFpEF）患者中也观察到了相同的显著趋势（sTIPS1与sTIPS0：HR = 1.366，95% CI 1.100 - 1.697，P = 0.005；sTIPS2与sTIPS0：HR = 1.995，95% CI 1.460 - 2.725，P<0.001）。然而，在射血分数轻度降低的心力衰竭（HFmrEF）患者（sTIPS1与sTIPS0：HR = 1.648，95% CI 1.238 - 2.194，P = 0.001）和射血分数降低的心力衰竭（HFrEF）患者（sTIPS1与sTIPS0：HR = 1.322，95% CI 1.021 - 1.712，P = 0.
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