Lemercier Clément E, Krieger Patrik, Manahan-Vaughan Denise
Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany.
iScience. 2024 Feb 29;27(4):109364. doi: 10.1016/j.isci.2024.109364. eCollection 2024 Apr 19.
Visual responses of the primary visual cortex (V1) are altered by sound. Sound-driven behavioral arousal suggests that, in addition to direct inputs from the primary auditory cortex (A1), multiple other sources may shape V1 responses to sound. Here, we show in anesthetized mice that sound (white noise, ≥70dB) drives a biphasic modulation of V1 visually driven gamma-band activity, comprising fast-transient inhibitory and slow, prolonged excitatory (A1-independent) arousal-driven components. An analogous yet quicker modulation of the visual response also occurred earlier in the visual pathway, at the level of the dorsolateral geniculate nucleus (dLGN), where sound transiently inhibited the early phasic visual response and subsequently induced a prolonged increase in tonic spiking activity and gamma rhythmicity. Our results demonstrate that sound-driven modulations of visual activity are not exclusive to V1 and suggest that thalamocortical inputs from the dLGN to V1 contribute to shaping V1 visual response to sound.
初级视觉皮层（V1）的视觉反应会受到声音的影响。声音驱动的行为唤醒表明，除了来自初级听觉皮层（A1）的直接输入外，其他多个来源可能会塑造V1对声音的反应。在这里，我们在麻醉的小鼠中发现，声音（白噪声，≥70分贝）驱动V1视觉驱动的伽马波段活动的双相调制，包括快速瞬态抑制和缓慢、持久的兴奋性（独立于A1）唤醒驱动成分。在视觉通路中更早的背外侧膝状核（dLGN）水平，也出现了类似但更快的视觉反应调制，在那里声音短暂抑制早期相位视觉反应，随后诱导紧张性放电活动和伽马节律的持续增加。我们的结果表明，声音驱动的视觉活动调制并非V1所特有，并表明从dLGN到V1的丘脑皮质输入有助于塑造V1对声音的视觉反应。
