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一个罕见病例:同时发生的集合管肾细胞癌和上尿路尿路上皮癌。

A curious case: Concurrent collecting duct renal cell carcinoma and upper tract urothelial carcinoma.

作者信息

Rahman Adib, Matheson Daniel, Perry-Keene Joanna, Desai Devang

机构信息

Department of Urology, Toowoomba Base Hospital, Queensland Health, Queensland, Australia.

Department of Pathology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.

出版信息

Urol Case Rep. 2024 Mar 9;54:102698. doi: 10.1016/j.eucr.2024.102698. eCollection 2024 May.

DOI:10.1016/j.eucr.2024.102698
PMID:38523833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10958685/
Abstract

A 71-year-old male presented to Urology with three weeks of overt haematuria and increasing lethargy. Contrast-enhanced CT scans revealed an 8 × 6cm partially exophytic lesion in the left kidney's upper pole, extending beyond the capsule and invading the superior cortical vein, accompanied by abnormal retrocrural lymph nodes. Signs of paraneoplastic syndrome prompted a left radical nephrectomy for symptom relief. Histological analysis identified high-grade collecting duct renal carcinoma and invasive urothelial cell carcinoma. Post-surgery, he was referred for oncological treatment but passed away within two months of the initial diagnosis.

摘要

一名71岁男性因三周肉眼血尿和日益加重的乏力症状前往泌尿外科就诊。增强CT扫描显示左肾上极有一个8×6cm的部分外生性病变,超出肾包膜并侵犯上皮质静脉,伴有膈脚后淋巴结异常。副肿瘤综合征的体征促使进行左肾根治性切除术以缓解症状。组织学分析确定为高级别集合管肾癌和浸润性尿路上皮癌。术后,他被转诊接受肿瘤治疗,但在初次诊断后的两个月内去世。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/2b9c7c33c183/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/ee11205ccc3f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/ffa0286dfde1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/d74e09aad8bb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/2b9c7c33c183/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/ee11205ccc3f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/ffa0286dfde1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/d74e09aad8bb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fec5/10958685/2b9c7c33c183/gr4.jpg

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本文引用的文献

1
Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease.集合管癌的最新进展:一种罕见病临床及分子特征的当前情况
Front Oncol. 2022 Oct 4;12:970199. doi: 10.3389/fonc.2022.970199. eCollection 2022.
2
PSMA PET/CT in Renal Cell Carcinoma: An Overview of Current Literature.前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描在肾细胞癌中的应用:当前文献综述
J Clin Med. 2022 Mar 25;11(7):1829. doi: 10.3390/jcm11071829.
3
Collecting Duct Carcinoma of the Kidney: Analysis of 74 Cases From Multiple Centers.
肾脏集合管癌:多中心 74 例分析。
Urology. 2022 Jun;164:163-168. doi: 10.1016/j.urology.2022.01.032. Epub 2022 Jan 31.
4
Incidence, Clinical Characteristics, and Survival of Collecting Duct Carcinoma of the Kidney: A Population-Based Study.肾集合管癌的发病率、临床特征及生存率:一项基于人群的研究
Front Oncol. 2021 Sep 14;11:727222. doi: 10.3389/fonc.2021.727222. eCollection 2021.
5
A rare case of collecting duct carcinoma with first presentation of respiratory symptoms.一例以呼吸道症状为首发表现的集合管癌罕见病例。
Urol Case Rep. 2020 Jul 29;33:101367. doi: 10.1016/j.eucr.2020.101367. eCollection 2020 Nov.
6
Survival Benefits Based on the Number of Lymph Nodes Removed during Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.基于上尿路尿路上皮癌根治性肾输尿管切除术中淋巴结清扫数量的生存获益:系统评价与荟萃分析
J Clin Med. 2020 Jun 21;9(6):1933. doi: 10.3390/jcm9061933.
7
Collecting ducts carcinoma: An orphan disease. Literature overview and future perspectives.集合管癌:一种孤儿病。文献综述与未来展望。
Cancer Treat Rev. 2019 Sep;79:101891. doi: 10.1016/j.ctrv.2019.101891. Epub 2019 Aug 27.
8
Prognosis and risk factors of patients with upper urinary tract urothelial carcinoma and postoperative recurrence of bladder cancer in central China.中国中部地区上尿路尿路上皮癌患者的预后和风险因素以及膀胱癌术后复发。
BMC Urol. 2019 Apr 18;19(1):24. doi: 10.1186/s12894-019-0457-5.
9
Bladder Cancer: Diagnosis and Treatment.膀胱癌:诊断与治疗
Am Fam Physician. 2017 Oct 15;96(8):507-514.
10
Collecting duct carcinoma of the kidney: Disease characteristics and treatment outcomes from the National Cancer Database.肾集合管癌:来自美国国立癌症数据库的疾病特征与治疗结果
Urol Oncol. 2017 Sep;35(9):540.e13-540.e18. doi: 10.1016/j.urolonc.2017.04.010. Epub 2017 May 8.