Kunioka Shingo, Suzuki Fumitaka, Nagata Marino, Tsutsui Masahiro, Kamiya Hiroyuki
Intensive Care Unit/Cardiac Surgery, Asahikawa Medical University, Asahikawa, JPN.
Cardiac Surgery, Asahikawa Medical University, Asahikawa, JPN.
Cureus. 2024 Feb 21;16(2):e54603. doi: 10.7759/cureus.54603. eCollection 2024 Feb.
The leukemoid reaction (LR) is reported to be caused by severe stress conditions such as infection, malignancies, intoxication, severe hemorrhage, or acute hemolysis; this condition is attributed to a very severe prognosis. Some reports have suggested that the LR was associated with a systemic stress response. A 36-year-old man who required mechanical circulatory support (MCS), including veno-arterial extracorporeal membrane oxygenation and Impella 5.5 due to severe heart failure, was transferred to our hospital. He showed a markedly elevated WBC count and died of multiple organ failure. The autopsy revealed the possibility that leukocytosis might have been due to an LR; however, the cause of the cardiac failure was unknown. To the best of our knowledge, this study is the first to report a rare case of LR in a patient with severe heart failure requiring MCS.
据报道，类白血病反应（LR）由严重应激状况引起，如感染、恶性肿瘤、中毒、严重出血或急性溶血；这种情况预后极差。一些报告表明，LR与全身应激反应有关。一名36岁男性因严重心力衰竭需要机械循环支持（MCS），包括静脉-动脉体外膜肺氧合和Impella 5.5，被转至我院。他的白细胞计数显著升高，最终死于多器官衰竭。尸检显示白细胞增多可能是由LR引起的；然而，心力衰竭的病因不明。据我们所知，本研究首次报道了一例罕见的类白血病反应病例，该病例为一名需要MCS的严重心力衰竭患者。
