Sakka Vissaria, Tsiodras Sotirios, Giamarellos-Bourboulis Evangelos J, Giamarellou Helen
4th Department of Internal Medicine, University General Hospital "ATTIKON", 1 Rimini Street, 124 62 Athens, Greece.
Eur J Intern Med. 2006 Oct;17(6):394-8. doi: 10.1016/j.ejim.2006.04.004.
Persistent neutrophilic leukocytosis above 50,000 cells/muL when the cause is other than leukemia defines a leukemoid reaction. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia (CML) and chronic neutrophilic leukemia (CNL) and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. The present article points out the difficulties in the differential diagnosis of a leukemoid reaction and suggests an algorithm for a rational clinical and laboratory evaluation of this problematic entity.
当病因不是白血病时，持续中性粒细胞增多超过50,000个/微升定义为类白血病反应。诊断检查包括排除慢性粒细胞白血病（CML）和慢性中性粒细胞白血病（CNL）以及检测潜在病因。类白血病反应的主要病因是严重感染、中毒、恶性肿瘤、严重出血或急性溶血。本文指出了类白血病反应鉴别诊断中的困难，并提出了一种对这一疑难病症进行合理临床和实验室评估的算法。
