Daniel Ebenezer, Deng Frank, Patel Sunita K, Sedrak Mina S, Young Jonathan, Kim Heeyoung, Razavi Marianne, Sun Can-Lan, Root James C, Ahles Tim A, Dale William, Chen Bihong T
Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States.
Department of Population Science, City of Hope National Medical Center, Duarte, CA, United States.
Front Aging Neurosci. 2024 Mar 8;16:1347721. doi: 10.3389/fnagi.2024.1347721. eCollection 2024.
The objective of this study was to assess changes in hippocampal volume and shape in older long-term breast cancer survivors who were exposed to chemotherapy 5-15 years prior.
This study recruited female long-term breast cancer survivors aged 65 years or older with a history of chemotherapy (C+), age-matched breast cancer survivors who did not receive chemotherapy (C-), and healthy controls (HC). The participants were recruited 5-15 years after chemotherapy at time point 1 (TP1) and were followed up for 2 years at time point 2 (TP2). Assessments included hippocampal volume and shape from brain MRI scans and neuropsychological (NP) tests.
At TP1, each of the three groups was comprised of 20 participants. The C+ group exhibited a hippocampal volume loss estimated in proportion with total intracranial volume (ICV) in both the left and right hemispheres from TP1 to TP2. Regarding the hippocampal shape at TP1, the C+ group displayed inward changes compared to the control groups. Within the C+ group, changes in right hippocampal volume adjusted with ICV were positively correlated with crystalized composite scores ( = 0.450, = 0.044). Additionally, in C+ groups, chronological age was negatively correlated with right hippocampal volume adjusted with ICV ( = -0.585, = 0.007).
The observed hippocampal volume reduction and inward shape deformation within the C+ group may serve as neural basis for cognitive changes in older long-term breast cancer survivors with history of chemotherapy treatment.
本研究的目的是评估5至15年前接受过化疗的老年长期乳腺癌幸存者海马体积和形状的变化。
本研究招募了65岁及以上有化疗史的女性长期乳腺癌幸存者（C+）、年龄匹配的未接受化疗的乳腺癌幸存者（C-）以及健康对照者（HC）。参与者在化疗后5至15年的时间点1（TP1）被招募，并在时间点2（TP2）进行了2年的随访。评估包括脑部MRI扫描的海马体积和形状以及神经心理学（NP）测试。
在TP1时，三组每组均有20名参与者。从TP1到TP2，C+组在左右半球均表现出海马体积损失，其损失与总颅内体积（ICV）成比例。关于TP1时的海马形状，与对照组相比，C+组表现出向内的变化。在C+组中，经ICV调整后的右侧海马体积变化与晶体化综合评分呈正相关（r = 0.450，p = 0.044）。此外，在C+组中，实际年龄与经ICV调整后的右侧海马体积呈负相关（r = -0.585，p = 0.007）。
在C+组中观察到的海马体积减少和形状向内变形可能是有化疗史的老年长期乳腺癌幸存者认知变化的神经基础。
