Tokui Hiroha, Yahata Hideaki, Okabe Yasuhiro, Magarifuchi Naomi, Maenohara Shoji, Hachisuga Kazuhisa, Tomonobe Hiroshi, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Onoyama Ichiro, Asanoma Kazuo, Oda Yoshinao, Nakamura Masafumi, Kato Kiyoko
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582 Japan.
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Int Cancer Conf J. 2024 Feb 14;13(2):162-166. doi: 10.1007/s13691-024-00659-5. eCollection 2024 Apr.
Adult granulosa cell tumors are rare, accounting for only 3-5% of all ovarian tumors. Adult granulosa cell tumors have late recurrences, for which complete resection is an effective option. We report a patient who underwent complete resection of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy. A 72-year-old woman underwent primary surgery for an adult granulosa cell tumor 19 years earlier. A huge recurrent tumor, 11 × 10 cm in size, was noted to elevate the hepatic hilum, inferior vena cava, and right renal vein. The recurrent tumor was too large to resect, thus paclitaxel and carboplatin were administered as neoadjuvant chemotherapy. The tumor shrank to 6 × 5 cm after 6 cycles of chemotherapy, then complete tumor extirpation with resection of the right kidney and temporary scission of inferior vena cava was performed. The patient was alive and well without evidence of a recurrence 1 y postoperatively. Paclitaxel and carboplatin, as neoadjuvant chemotherapy, might be an effective treatment option to achieve complete reduction surgery. This is the first report demonstrating the effectiveness of paclitaxel and carboplatin for huge recurrent adult granulosa cell tumor.
成人颗粒细胞瘤较为罕见，仅占所有卵巢肿瘤的3% - 5%。成人颗粒细胞瘤复发较晚，完整切除是一种有效的治疗选择。我们报告一例患者，其在新辅助化疗后接受了巨大复发性成人颗粒细胞瘤的完整切除。一名72岁女性19年前因成人颗粒细胞瘤接受了初次手术。发现一个巨大的复发性肿瘤，大小为11×10厘米，抬高了肝门、下腔静脉和右肾静脉。复发性肿瘤太大无法切除，因此给予紫杉醇和卡铂作为新辅助化疗。化疗6个周期后肿瘤缩小至6×5厘米，随后进行了肿瘤完整切除，包括右肾切除和下腔静脉临时切断。术后1年患者存活且状况良好，无复发迹象。紫杉醇和卡铂作为新辅助化疗，可能是实现完全减瘤手术的有效治疗选择。这是首例证明紫杉醇和卡铂对巨大复发性成人颗粒细胞瘤有效的报告。
