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嗜酸性中耳炎中细胞因子及前列腺素代谢相关蛋白的基因表达

Gene expression of cytokines and prostaglandin metabolism-related proteins in eosinophilic otitis media.

作者信息

Oka Aiko, Takahashi Masahiro, Nishimura Wataru, Oyamada Shogo, Oka Shinichiro, Iwasaki Satoshi, Kanai Kengo, Okano Mitsuhiro

机构信息

Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan.

Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.

出版信息

J Allergy Clin Immunol Glob. 2024 Mar 1;3(2):100237. doi: 10.1016/j.jacig.2024.100237. eCollection 2024 May.

DOI:10.1016/j.jacig.2024.100237
PMID:38524784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10959659/
Abstract

The objective of this study was to investigate the levels of gene expression in the middle ear mucosa of 2 patients diagnosed with eosinophilic otitis media. One patient with severe hearing loss showed high expression levels of genes encoding IL-5 and IL-33 receptors.

摘要

本研究的目的是调查2例被诊断为嗜酸性粒细胞性中耳炎患者的中耳黏膜中的基因表达水平。1例重度听力损失患者显示出编码IL-5和IL-33受体的基因的高表达水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/51b7fe352f1d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/a2c31ed43f28/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/3a5b5d47dc65/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/51b7fe352f1d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/a2c31ed43f28/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/3a5b5d47dc65/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5926/10959659/51b7fe352f1d/gr3.jpg

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2
Eosinophilic otitis media; state-of-the-art diagnosis and treatment.嗜酸细胞性中耳炎；最新诊断与治疗。
Auris Nasus Larynx. 2023 Aug;50(4):479-489. doi: 10.1016/j.anl.2022.11.004. Epub 2022 Dec 15.
3
Risk factors for bacterial infection to cause sensorineural hearing loss in eosinophilic otitis media.
嗜酸细胞性中耳炎致感音神经性聋细菌感染的危险因素。
Auris Nasus Larynx. 2021 Apr;48(2):207-213. doi: 10.1016/j.anl.2020.08.001. Epub 2020 Sep 1.
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Biology and therapeutic potential of interleukin-10.白细胞介素-10 的生物学特性和治疗潜力
J Exp Med. 2020 Jan 6;217(1). doi: 10.1084/jem.20190418.
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Cardio-renal safety of non-steroidal anti-inflammatory drugs.非甾体抗炎药的心脏-肾脏安全性
J Toxicol Sci. 2019;44(6):373-391. doi: 10.2131/jts.44.373.
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