Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Novartis Institute for Biomedical Research, Cambridge, MA, USA.
Immunity. 2019 Apr 16;50(4):796-811. doi: 10.1016/j.immuni.2019.03.022.
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Here, we review the functions of the β common cytokines in health and disease. We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of the basic biology of this cytokine family.
β 共用链细胞因子 GM-CSF、IL-3 和 IL-5 调节多种炎症反应，促进病原体的快速清除，但也导致慢性炎症中的病理变化。调节这些细胞因子的治疗干预措施已被批准用于某些癌症以及过敏性和自身免疫性疾病，其他一些则显示出有希望的早期临床活性。这些方法基于我们对这些细胞因子炎症作用的理解；然而，GM-CSF 也参与炎症的消退，IL-3 和 IL-5 也可能具有这种特性。在这里，我们回顾了 β 共用细胞因子在健康和疾病中的功能。我们讨论了临床前和临床数据，强调了靶向这些细胞因子途径的潜力、局限性以及对该细胞因子家族基础生物学理解的重要差距。
